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    Did you mean 5α-reductase inhibitors?
    Glossary 5α-reductase inhibitors

    block enzyme converting testosterone to hair-loss-causing DHT

    5α-reductase inhibitors, also known as 5-ARIs, are medications that block the enzyme 5α-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), a hormone that can contribute to conditions like male pattern baldness and benign prostatic hyperplasia (BPH). By inhibiting this enzyme, 5-ARIs can help reduce hair loss and shrink an enlarged prostate.

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    1. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    2. The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention 2011 · 147 citations
    3. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012 · 124 citations
    4. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017 · 90 citations
    5. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016 · 57 citations
    6. The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog <i>Silurana tropicalis</i> Sexual Development · 2009 · 37 citations
    7. Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013 · 34 citations
    8. <i>Curcuma aeruginosa</i>, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study Journal of Dermatological Treatment · 2011 · 34 citations
    9. 12 Treatment of hirsutism with 5α-reductase inhibitors Clinics in endocrinology and metabolism · 1986 · 28 citations
    10. New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors. Chemical & Pharmaceutical Bulletin · 2001 · 22 citations
    11. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    12. Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors Bioorganic & Medicinal Chemistry · 2015 · 17 citations
    13. Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size Steroids · 2009 · 15 citations
    14. New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors Steroids · 2011 · 14 citations
    15. Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors Chemical & Pharmaceutical Bulletin · 2017 · 13 citations
    16. Inhibitors of 5α-reductase-related side effects in patients seeking medical care for sexual dysfunction. PubMed · 2012 · 13 citations
    17. 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1 Bioorganic & medicinal chemistry letters · 2007 · 13 citations
    18. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    19. COMBINATION OF AN ANTIANDROGEN AND A 5α-REDUCTASE INHIBITOR: A FURTHER STEP TOWARDS TOTAL ANDROGEN BLOCKADE? Endocrinology · 1991 · 9 citations
    20. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    21. Re: Risk of Erectile Dysfunction Associated with Use of 5α-Reductase Inhibitors for Benign Prostatic Hyperplasia or Alopecia: Population Based Studies Using the Clinical Practice Research Datalink European Urology · 2017 · 2 citations
    22. Association Between 5α-Reductase Inhibitors and Prostate Cancer Mortality The International Journal of Medical Science and Health Research · 2024 · 1 citations
    23. Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone. Letter. The Journal of Urology · 2022 · 1 citations
    24. Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors Current Drug Discovery Technologies · 2020 · 1 citations
    25. Antioxidant and 5α-Reductase Inhibitory Activity of Momordica charantia Extract, and Development and Characterization of Microemulsion Applied sciences · 2022 · 1 citations
    26. Re: Association of Suicidality and Depression with 5α-Reductase Inhibitors 2017 · 1 citations
    27. Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques Frontiers in Bioinformatics · 2025
    28. The relevance of using 5α-reductase inhibitors in the conservative management of benign prostatic hyperplasia: A review Consilium Medicum · 2025
    29. Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals 2025
    30. Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals Saudi Journal of Medicine and Public Health · 2025