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research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)
The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.
research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase
Glioblastoma cells can make androgens, which might help the tumor grow.
research The Free Communications of the Eighth Clinical Congress (Virtual) of the Gulf Chapter of the American Association of Clinical Endocrinologists; November 5–7, 2020
I'm sorry, but I can't provide a summary without the content of the document.
research Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006
Spermidine may help extend the growth phase of hair.
research Response to Comments on the Scientific Opinion on the Substantiation of a Health Claim Related to Spermidine and Prolongation of the Growing Phase (Anagen) of the Hair Cycle Pursuant to Article 13(5) of Regulation (EC) No 1924/2006
The EFSA maintained its view that spermidine's effect on hair growth is related to disease treatment and does not meet the health claim criteria.
research Co-Sponsored by the International Society of Hair Restoration Surgery: Live Surgery Workshop XI: Advancing the Industry of Hair Restoration, March 2–5, 2005, Orlando
research Use of Urinary Bladder Matrix, a Bioactive, Acellular Scaffold Along with Platelet-Rich Plasma in Transplant Donor Scars and Androgenetic Alopecia: 5-Year Experience in Hair Duplication and Hair Loss Prevention/Non-Surgical Restoration
Using urinary bladder matrix and platelet rich plasma can effectively treat transplant scars and prevent hair loss.
research A Double Blind, Randomised, Vehicle-Controlled, Safety and Tolerance Study of Topical PSK 3841 Solution at 5% Administered Twice Daily Over Four Weeks to Healthy Caucasian Males with Androgenetic Alopecia
research A Multi-Centre, Double-Blind, Randomised, Vehicle-Controlled Study for a Quantitative Estimation of Hair Re-Growth in Male Subjects with Androgenetic Alopecia Treated Over 6 Months with Two Ethanolic PSK 3841 Solutions (2.5% and 5%)
research Scientific Opinion on the Substantiation of a Health Claim Related to a Combination of Thiamin, Riboflavin, Niacin, Pantothenic Acid, Pyridoxine, D-Biotin, and Pumpkin Seed Oil and Maintenance of Normal Hair Pursuant to Article 13(5) of Regulation (EC) No 1924/2006
The combination of certain vitamins and pumpkin seed oil has not been proven to maintain normal hair.
research The Association of Urolithiasis and Androgenetic Alopecia
Kidney stones and hair loss are significantly related in people under 60 years old.
research 5α-Reductase Activity in the Prostate
Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review
No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.
research Topical Minoxidil for Hair Regrowth
5% minoxidil helps hair regrowth in androgenic alopecia.
research 5α-Reduced Glucocorticoids: A Story of Natural Selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
research 5α-Reductases in Human Physiology: An Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
research Medical Therapy for Frontal Fibrosing Alopecia: A Review and Clinical Approach
Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.
research Five-Alpha-Reductase Inhibitors for Prostate Cancer Prevention
5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.
research Guidelines for Management of Androgenetic Alopecia Based on BASP Classification: The Asian Consensus Committee Guideline
Use 5% minoxidil or oral finasteride for mild-to-moderate hair loss, combine with hair transplant for severe cases.
research 5α-Reductase Activity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.
research Molecular Interactions of New Pregnenedione Derivatives
The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
research Androgenetic Alopecia
Androgenetic alopecia is a common hair loss condition caused by testosterone effects on hair follicles, leading to thinner, shorter, and less pigmented hair, diagnosed using scalp dermoscopy and treated with topical minoxidil, antiandrogen agents, and 5-alpha reductase inhibitors.
research Usefulness of Home-Use Microneedle Devices in the Treatment of Pattern Hair Loss
Home-use microneedle devices might safely boost 5% minoxidil's effectiveness for hair growth.
research Other Antiandrogens: Alternative Treatments for Acne and Hirsutism
Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.
research Proton Affinitive Derivatization for Highly Sensitive Determination of Testosterone and Dihydrotestosterone in Saliva Samples by LC-ESI-MS/MS
Using 5-butylpicolinate esters improves the sensitivity and reliability of detecting testosterone and dihydrotestosterone in saliva.
research Association Between Gender and Drug Cost for Over-the-Counter Minoxidil
Women pay more for the same 5% minoxidil foam than men, but prices for liquid solutions are similar.
research Effect of Finasteride on Adrenal Steroidogenesis in Men
Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.
research Impact of Anti-Androgen Therapies on COVID-19 Susceptibility: A Case-Control Study in Male Population from Two COVID-19 Regional Centers of Lombardy, Italy
Men taking 5-alpha reductase inhibitors for prostate issues may be less likely to experience severe COVID-19, but it doesn't prevent ICU admission or death.
research Patterns of Care for Newly Diagnosed Benign Prostatic Hyperplasia in the United States
Most care for benign prostatic hyperplasia follows guidelines, but 5-α reductase inhibitors are often used incorrectly.