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The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.

Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The study created a new method to test drugs that affect hormone processing in skin.

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

Betula platyphylla extract, particularly the H3-2 fraction, may help treat hair loss by promoting cell growth and inhibiting a hair loss-related enzyme.

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Testosterone's muscle-building effects do not require its conversion to DHT.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

5α-reductase inhibitors like finasteride and dutasteride can help treat skin disorders stimulated by androgens, such as hair loss and acne.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Phytoconstituents from Cyperus Rotundus may help treat hirsutism by interacting with the 5 α reductase enzyme.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Finasteride use during early pregnancy may cause limb deformities in babies.

Early onset hair loss linked to genetics and androgen levels.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.

Pumpkin seed oil helps hair growth in men with hair loss.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Higher dihydrotestosterone may be linked to more inflammation in COVID-19 patients with low testosterone.