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community Increasing GH and IGF-1 for Increased Growth/Reduced Hair Loss?

4 upvotes 2 years ago

Increasing IGF-1 may help hair growth, but it could also increase hair loss in people with high testosterone. Treatments discussed include l-arginine, glutamine, vanadium, Deer Antler Velvet, ATP, Cocarboxylase, l-carnitine, and Mk677.

community Serum based on plant extracts boosts hair growth in weeks.

44 upvotes 11 months ago

A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

community My experience with MK-677 and hairloss. (positive, but completely anecdotal)

5 upvotes 11 years ago

MK-677 (Ibutamoren) helped reduce hair shedding and improved muscle growth for the user. The user advises caution, noting increased appetite and potential weight gain without exercise.

community How Fast Weight Loss Causes Hair Loss (and how to mitigate it)

43 upvotes 3 months ago

Rapid weight loss can cause hair loss due to a surge in free fatty acids and reduced protein intake, leading to Telogen effluvium. A safe weight loss rate is 0.5-1.2 lbs per week with adequate protein intake to mitigate hair loss.

community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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Research

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research The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq

July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels than controls, suggesting a possible role for IGF-1 in this condition.

research The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq

July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels compared to controls, but no significant association between IGFBP-3 levels and hair loss severity was observed.

research The Association between Low (or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case-Control Study in Basrah, Iraq

March 2026 in “European Journal of Medical and Health Research”

In this case-control study, researchers observed that women with female pattern hair loss exhibited significantly lower serum IGF-1 levels than controls, while IGFBP-3 levels showed no significant difference, suggesting a potential role for IGF-1 in the condition.

research Endocrine disorders in Woodhouse-Sakati syndrome: a systematic review of the literature

31 citations , January 2014 in “Journal of endocrinological investigation”

This study reviewed Woodhouse-Sakati syndrome and found it consistently associated with hypogonadism, decreased IGF1, and frontotemporal alopecia, with additional symptoms like intellectual disabilities and diabetes in some patients.

research SMC-specific IGF1 suppresses a 45 kDa LAMP2 isoform to mediate the anti-atherosclerotic effect of ferulic acid

August 2026 in “Frontiers in Pharmacology”

This study found that ferulic acid treatment significantly reduced atherosclerotic plaque in mice, partly through smooth muscle cell-derived IGF1-mediated regulation of lysosomal and inflammatory pathways.

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Learn

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learn sh-Polypeptide-7

Does sh-Polypeptide-7 stimulate hair follicles or reduce scalp inflammation? sh-Polypeptide-7 is the INCI name for a lab-made form of human growth hormone (somatotropin) — not EGF, which is sh-Oligopeptide-1. Growth hormone and IGF-1 signalling is documented in hair follicle biology, but there is no published human trial of sh-Polypeptide-7 applied to the scalp for hair growth or scalp inflammation.

learn Botox

Can Botox reduce chronic hair shedding? Whether Botox reduces chronic shedding is unknown: one very small 2022 trial in telogen effluvium had no placebo arm, and the blood-flow theory is unproven. Scalp Botox for hair loss is off-label, and all botulinum toxin products carry an FDA boxed warning.

learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Folic acid

Can folic acid help reduce hair loss in men and women, and how should it be taken? Correcting a confirmed folate deficiency is reasonable, but no published trial shows folic acid supplementation reduces hair loss on its own; the evidence is a few small observational studies and reviews that call for proper trials.

learn Ginkgo biloba

Can ginkgo biloba reduce scalp inflammation that contributes to hair loss? There is no human evidence that ginkgo reduces scalp inflammation or helps hair loss. Ginkgo may increase bleeding risk and interact with medicines, so talk to a doctor or pharmacist first.

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