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In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.

Early treatment of mixed connective tissue disease is crucial to prevent severe autoimmune conditions.

Popliteal Artery Entrapment Syndrome (PAES) is a rare but possible cause of leg pain during walking, even in untrained women.

Pincer nails are rare in lupus patients and may be managed conservatively.

Skin problems are very common in people with systemic lupus erythematosus and important for diagnosis.