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GlossaryRenin-Angiotensin System (RAAS)

hormone system regulating blood pressure and fluid balance

The Renin-Angiotensin System (RAS), also known as the Renin-Angiotensin-Aldosterone System (RAAS), is a hormone system that regulates blood pressure and fluid balance in the body. When blood pressure drops, the kidneys release the enzyme renin, which triggers a cascade of reactions leading to the production of angiotensin II, a potent vasoconstrictor that increases blood pressure and stimulates the release of aldosterone from the adrenal glands, promoting sodium and water retention.

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research Repurposing Existing Drugs for COVID-19: An Endocrinology Perspective

34 citations , September 2020 in “BMC Endocrine Disorders”

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

research Hypertension and Cicatricial Hair Loss: Defining High Value Symptom Clusters Within Reproductive Aging

1 citations , March 2021 in “Journal of Dermatology Research and Therapy”

Women with cicatricial hair loss may have a higher risk of hypertension.

research The Impact of Angiotensin-Converting Enzyme 2 Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

52 citations , August 2021 in “Microorganisms”

Higher ACE2 levels in certain tissues may worsen COVID-19 in people with other health issues, especially older adults.

research Human Genetic Basis of Coronavirus Disease 2019

38 citations , September 2021 in “Signal Transduction and Targeted Therapy”

Genetic differences affect COVID-19 severity and treatment development.

research Protective Cardiovascular and Renal Actions of Vitamin D and Estrogen

13 citations , December 2012 in “Frontiers in bioscience”

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

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community P-1075: a BETTER version of Minoxidil

in Research/Science 3 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community New 2025 study: high dose oral minoxidil (up to 10mg)

in Research/Science 80 upvotes 4 months ago

High-dose oral minoxidil (>5 mg/day) can increase hair density in some men with androgenetic alopecia, but side effects like extra body hair and heart issues are common. Gradual dose increase is advised, but adverse effects may lead to discontinuation or dose adjustments.

community The Fear of Oral Minoxidil is Overblown

in Research/Science 273 upvotes 7 months ago

Low-dose oral minoxidil is a safe and effective hair loss treatment with fewer side effects than previously feared. Users often prefer it over topical minoxidil for better results, though some experience side effects like increased body hair and cardiovascular issues.