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research Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

10 citations , June 2018 in “Journal of visualized experiments”

This study demonstrated that lactate dehydrogenase activity is notably high in quiescent hair follicle stem cells within mouse skin using a specific enzymatic activity assay.

research LB1045 Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo

July 2024 in “Journal of Investigative Dermatology”

PP405 may help hair growth by activating hair follicle stem cells.

research Lactate dehydrogenase activity drives hair follicle stem cell activation

202 citations , August 2017 in “Nature cell biology”

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

research Modulating Aging and Aging-related Symptoms Using Endogenous Small Molecules

January 2019

This study identified that α-ketobutyrate (α-KB) extends lifespan and improves health markers in Caenorhabditis elegans and aged mice by modulating pyruvate metabolism and activating AMPK pathways, with potential implications for human anti-aging treatments.

research Fibroblasts as the subject of proliferative activity research in vitro

7 citations , October 2020 in “Science and Innovations in Medicine”

This review discusses how fibroblast metabolic processes and life span are influenced by the malate dehydrogenase shuttle system and highlights factors affecting fibroblast proliferative activity, without presenting new experimental results.

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community PP405 Identity Research

in Research 292 upvotes 1 year ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Anyone heard of scube3? And other emerging treatments?

in Research/Science 4 upvotes 1 year ago

Emerging hair loss treatments like PP405, a topical MPC inhibitor, show promise in activating stem cells for hair growth. The conversation seeks information on the development stages and accessibility of these treatments.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

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mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

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