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In this study, formulations of a typical lotion shampoo with ethanol or propylene glycol increased the in-vitro release rate of zinc pyrithione, an anti-dandruff agent.

In this study, researchers developed a method using scalp cyanoacrylate biopsy and advanced imaging techniques to effectively measure and visualize the distribution of anti-dandruff shampoo ingredients zinc pyrithione and climbazole within the scalp follicular infundibulum.

This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.

This study found that daily use of 1% pyrithione zinc shampoo modestly improved hair growth over 26 weeks, although these effects were less than those of 5% minoxidil.

Most women preferred the 1% pyrithione zinc shampoo for better hair smoothness and less frizz while controlling dandruff.