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Glossary Punch Biopsy

removal of a small, circular skin sample for examination

A punch biopsy is a medical procedure used to remove a small, circular section of tissue from the skin for examination. This is done using a sharp, hollow instrument called a punch, which is rotated into the skin to extract a core of tissue. It is commonly used to diagnose skin conditions, including alopecia, by allowing for microscopic analysis of the sampled tissue.

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Research

5 / 1000+ results

research Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay”

5 citations , July 2018 in “Experimental Dermatology”

In this study, researchers developed a relatively simple punch assay for regenerating hair follicles using mouse or human cells, finding efficient hair formation with mouse cells but low efficiency with human cells on reconstituted human skin.

research Alopecias: Practical Tips for the Management of Biopsies and Main Diagnostic Clues for General Pathologists and Dermatopathologists

July 2023 in “Journal of Clinical Medicine”

This paper identifies challenges in diagnosing alopecia variants, emphasizing the importance of pathologists understanding hair follicle histology, biopsy types, and collaborating with dermatologists to improve diagnostic accuracy.

research It's not all traction: the pseudo ‘fringe sign’ in frontal fibrosing alopecia

39 citations , July 2015 in “British Journal of Dermatology”

This article discusses the pseudo 'fringe sign' in frontal fibrosing alopecia, highlighting that it is not solely related to traction, and it reports no new clinical results.

research Morphological Approach to Hair Disorders

38 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews various topics discussed at a workshop on hair disorders, focusing on hair biology, diagnosis, and challenges in therapy evaluation, without presenting new clinical findings.

research Common Dermatologic Procedures

9 citations , September 2015 in “Medical Clinics of North America”

This article reviews common dermatologic procedures, focusing on skin biopsy techniques, with no new clinical results reported.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

41 upvotes 1 year ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

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