Search
for

    Did you mean Progerin?
    Glossary Progerin

    defective protein causing premature aging in Hutchinson-Gilford Progeria Syndrome

    Progerin is a defective protein that is produced in cells due to a mutation in the LMNA gene, which normally codes for the lamin A protein. This abnormal protein is associated with Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder that causes accelerated aging in children. Progerin disrupts the normal structure and function of the cell nucleus, leading to various symptoms of premature aging.

    Related Terms

    Research 10 of 177

    1. Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease Journal of Cell Science · 2008 · 85 citations
    2. Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells Cells · 2019 · 51 citations
    3. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin Human Molecular Genetics · 2008 · 48 citations
    4. Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment Cells · 2019 · 39 citations
    5. Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis EMBO molecular medicine · 2019 · 11 citations
    6. Hutchinson-gilford progeria syndrome and its relevance to cardiovascular diseases and normal aging. PubMed · 2013 · 3 citations
    7. Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case Вопросы современной педиатрии · 2022 · 1 citations
    8. Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome International journal of molecular sciences · 2022 · 1 citations
    9. Ocular manifestation in progeria: A case report Nepalese journal of ophthalmology · 2020
    10. Genetics of Progeria and Aging Elsevier eBooks · 2018
    All research results →

    Learn

    — no results

    Try a deeper search in learn →

    Community

    — no results

    Try a deeper search in community →