This study found that among women with diffuse hairloss, 26.2% had a history of drug intake, with antihypertensives being the most common drug group implicated.
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September 2019 in “Journal of Orthodontics”
In this study, a 13-year-old boy developed temporary pressure alopecia from wearing orthodontic headgear, which resolved after discontinuation, highlighting a rare side effect that can affect psychosocial wellbeing.
February 2025 in “International Journal of Dermatology”
In this review, researchers examined pressure alopecia related to injectable treatments, identifying that injected volume can compress blood vessels, leading to hairloss through ischemia and inflammation, which emphasizes the need for targeted risk management and therapeutic strategies in dermatology.
This article discusses the historic use of oral minoxidil for severe hypertension and the subsequent development of a topical formulation for treating pattern hairloss, but reports no new results.
This review explores the potential connection between GA and various types of alopecia but reports no new clinical findings, emphasizing the need for further research.
A permanent hairloss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.
GT20029 is a new hairloss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.
Low-dose oral minoxidil is used for hairloss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.
South Korea is debating whether hairloss treatments should be covered by public healthcare, highlighting the issue's impact on mental health and social functioning. The discussion centers on whether hairloss should be classified as a medical condition rather than a cosmetic issue, considering its psychological effects and the biological processes involved.
Got small bald patches they say are from stress? PP405 sprays could help bring them back to life.PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.
Tried everything and still getting bald patches? Procapil may help calm the immune responseProcapil is a cosmetic ingredient complex; laboratory studies of its individual ingredients report anti-inflammatory effects, but no published clinical trial has tested it in alopecia areata or any other immune-related hair loss. Spreading bald patches should be assessed by a dermatologist.
Can a zinc deficiency directly cause hair thinning or increased shedding?Studies link low serum zinc to diffuse shedding and alopecia areata, and severe deficiency states cause hair loss that reverses when zinc is replaced. The evidence is mostly observational, the one supplementation study was small and uncontrolled, and zinc is not a treatment for pattern hair loss.