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research Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

December 2016 in “Springer eBooks”

This review examines the clinical features, causes, diagnosis, and treatment of Chrousos syndrome but reports no new experimental findings on this condition.

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations , October 2008 in “Endocrine reviews”

This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.

research The Dermis of Millivora Capenesis

February 2019 in “American International Journal of Humanities Arts and Social Sciences”

This histological study of Millivora Capenesis skin describes the composition of the dermis, featuring distinct papillary and reticular layers with associated structures like hair follicles, glands, and corpuscles.

Pharmacological Activity and Clinical Use of Polydeoxyribonucleotide

research Pharmacological Activity and Clinical Use of PDRN

80 citations , April 2017 in “Frontiers in Pharmacology”

This review examines experimental and clinical evidence on PDRN, a drug derived from salmon DNA that acts via the adenosine A2A receptor and shows promise for tissue repair and treatment of diabetic foot ulcers in regenerative medicine.

research Polydeoxyribonucleotide as a Regenerative Agent in Dermatology and Wound Healing: Mechanisms, Clinical Applications, and Safety

3 citations , June 2025 in “Gyemyeong uidae haksulji”

This review suggests that PDRN shows promise as a safe and versatile regenerative agent for wound healing and other dermatological applications, based on its dual mechanisms and clinical evidence of efficacy.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Finasteride's impact on blood pressure - mechanism of action

4 upvotes 5 years ago

Finasteride may cause mild blood pressure-related side effects in less than 10% of users, unlike minoxidil, which has stronger effects. Alternatives like topical ketoconazole and dermarollers are suggested for those concerned about finasteride's side effects.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

97 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 1 month ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community Ru58841 ruined my life. Here’s why.

132 upvotes 4 years ago

User experienced shortness of breath, high blood pressure, red eyes, and eye floaters after using RU58841 for hair loss. They warn others to avoid RU58841 and stick to finasteride, minoxidil, and dutasteride.

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