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research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility1

35 citations , October 2004 in “Biology of Reproduction”

This study found that dual 5α-reductase inhibition in rats led to decreased sperm motility and altered morphology, resulting in subfertility.

research PNU 157706, a novel dual type I and II5α-reductase inhibitor

42 citations , February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.

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