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research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1

3 citations , June 2018 in “Bioorganic & medicinal chemistry”

This study identified that derivatives 4, 4b, and 4c strongly inhibited the enzyme type 1 5α-reductase and decreased reproductive organ weights in hamsters, suggesting potential as prodrugs for prostate tumor growth inhibition.

research Nanocarriers for Improved Delivery of Angiotensin-(1-7)

January 2015 in “Elsevier eBooks”

This chapter reviews the use of liposomes and cyclodextrins to improve the delivery and effectiveness of the peptide angiotensin-(1-7) in various therapeutic applications and reports no new experimental results.

The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

research The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

33 citations , November 2008 in “European Journal of Pharmaceutical Sciences”

This study found that St. John's wort treatment for two weeks induced finasteride metabolism and reduced its plasma exposure in healthy men.

research Sublingual tofacitinib for alopecia areata: a roll‐over pilot clinical trial and analysis of pharmacokinetics

9 citations , May 2021 in “International Journal of Dermatology”

In this study, sublingual tofacitinib achieved a longer estimated half-life than oral administration in treatment-resistant alopecia areata patients, potentially supporting daily dosing; overall treatment response was modest.

research Bioequivalance of single oral administration of finasteride tablet and capsule in healthy volunteers

January 2004

This study found that the finasteride tablet and capsule are bioequivalent to the control finasteride tablet in healthy volunteers.

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community Dutasteride half life - conflicting information

9 upvotes 2 years ago

The half-life of Dutasteride is commonly stated as around 5 weeks, but some sources suggest it is 170 hours for men aged 20–49, with further information indicating it varies from 3 days to 5 weeks depending on the dose. The user is seeking clarity on these conflicting figures.

community Dutasteride actually has different half lives depending on dose

in Research/Science 37 upvotes 1 year ago

Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.

community How I treat my hairloss with dutasteride, minoxidil and tretinoin for around £280 a year (UK)

in Research/Science 25 upvotes 6 months ago

The user treats hair loss with dutasteride, minoxidil, and tretinoin for about £280 a year by using dutasteride weekly due to its long half-life, while using minoxidil daily. Concerns about the shelf life and absorption of topical treatments were discussed, with some users suggesting alternative sources for these products.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Do I give up? A year and a half on min/fin

23 upvotes 3 weeks ago

The user experienced initial hair growth with minoxidil and finasteride but lost progress due to inconsistent use. Suggestions include switching to dutasteride for better results and maintaining consistency.

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Learn

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learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Overview

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