152 citations
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March 1988 in “Journal of The American Academy of Dermatology” Superficial granulomatous pyoderma is a unique, mild form of skin disease that often heals without strong medication and responds well to milder treatments.
489 citations
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November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
1 citations
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January 2023 in “Indian Dermatology Online Journal” This observational study, conducted on 172 patients with hematolymphoid neoplasms undergoing chemotherapy, found that 15.6% exhibited skin manifestations related to their malignancy, with 4.6% showing direct malignant cell infiltration. Chemotherapy-induced effects were prevalent, with 46.5% experiencing alopecia, particularly linked to cytarabine and methotrexate, and 47.1% having nail changes. Common non-infectious manifestations included cutaneous hyperpigmentation (31.4%) and xerosis (18.6%). The study emphasized the diagnostic challenges and significant impact on quality of life, advocating for early recognition and a multidisciplinary approach to manage these effects. Limitations included difficulties in histopathological confirmation and drug association due to polypharmacy.
318 citations
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January 2022 in “Signal Transduction and Targeted Therapy” The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
11 citations
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September 1999 in “Journal of the European Academy of Dermatology and Venereology” Immunomodulatory therapies are effective for treating cutaneous lymphoma, particularly in early stages.