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GlossaryPhosphatidic Acid (phosphatidate)

lipid molecule involved in cell membrane structure and signaling

Phosphatidic Acid (PA) is a type of lipid molecule that plays a crucial role in the structure and function of cell membranes. It acts as a precursor for the biosynthesis of other lipids and is involved in cell signaling pathways that regulate various cellular processes, including growth and metabolism.

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Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations, September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Decreased Lipin 1β Expression in Visceral Adipose Tissue Is Associated with Insulin Resistance in Polycystic Ovary Syndrome

20 citations, October 2008 in “European journal of endocrinology”

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

research Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

46 citations, August 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Phosphatidic acid may help hair grow by affecting cell growth pathways.

research The Human Gut Chemical Landscape Predicts Microbe-Mediated Biotransformation of Foods and Drugs

36 citations, June 2019 in “eLife”

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

research Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue

18 citations, May 2018 in “International Journal of Molecular Sciences”

Human body's immune cells are more common in the layer of fat just beneath the skin than in deeper fat layers.

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