38 citations,
June 2018 in “Archives of Toxicology”
Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
A PhaseII clinical trial for TDM-105795 has started recruiting in the US, and it might be a promising treatment for hair loss. Many hair loss drugs, including this one, originate from China.
PhaseII for TDM-105795 for Androgenic Alopecia is set to begin in April 2023. The study aims to evaluate the efficacy and safety of TDM-105795 in male subjects.
The conversation is about the anticipated release date of phaseII results for a hair loss treatment called GT20029 and the cautious optimism surrounding it due to past disappointments with similar treatments. Users expect an update in the next few months.
GT20029 showed significant hair growth and safety in phaseII trials, with no adverse sexual events. Users are hopeful but concerned about future costs and systemic effects.
The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China PhaseII trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate PhaseIII trials in China and PhaseII in the U.S., and the treatment also shows promise for acne.