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    Glossary Epidermal Permeability Barrier

    outermost skin layer preventing water loss and blocking pathogens

    The Epidermal Permeability Barrier is a critical function of the outermost layer of the skin, known as the stratum corneum. It prevents excessive water loss from the body and protects against the entry of harmful substances and microorganisms. This barrier is maintained by a complex mixture of lipids, proteins, and other molecules that work together to keep the skin hydrated and intact.

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    1. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    2. Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia American Journal Of Pathology · 2008 · 100 citations
    3. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo Mechanisms of Development · 2003 · 46 citations
    4. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    5. Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice Mechanisms of development · 2005 · 63 citations
    6. Does dry skin indicate defective epidermal permeability barrier? Chinese Journal of Dermatology · 2022
    7. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011 · 86 citations
    8. 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions Journal of Investigative Dermatology · 2017
    9. Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions Biological Chemistry · 2008 · 84 citations
    10. Tight junctions form a barrier in porcine hair follicles European journal of cell biology · 2015 · 21 citations
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