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    Glossary Epidermal Permeability Barrier

    outermost skin layer preventing water loss and blocking pathogens

    The Epidermal Permeability Barrier is a critical function of the outermost layer of the skin, known as the stratum corneum. It prevents excessive water loss from the body and protects against the entry of harmful substances and microorganisms. This barrier is maintained by a complex mixture of lipids, proteins, and other molecules that work together to keep the skin hydrated and intact.

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    1. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    2. Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia American Journal Of Pathology · 2008 · 100 citations
    3. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo Mechanisms of Development · 2003 · 46 citations
    4. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    5. Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice Mechanisms of development · 2005 · 63 citations
    6. Does dry skin indicate defective epidermal permeability barrier? Chinese Journal of Dermatology · 2022
    7. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011 · 86 citations
    8. 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions Journal of Investigative Dermatology · 2017
    9. Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions Biological Chemistry · 2008 · 84 citations
    10. Tight junctions form a barrier in porcine hair follicles European journal of cell biology · 2015 · 21 citations
    11. Epidermal pigmentation in the human lineage is an adaptation to ultraviolet radiation 2013 · 62 citations
    12. Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines American Journal Of Pathology · 2018 · 21 citations
    13. The Endocrine Function of the Skin: An Analytical Narrative Apollo medicine · 2023
    14. The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids Human health handbooks · 2012 · 1 citations
    15. Penetration of drugs through skin, a complex rate-controlling membrane 2012 · 211 citations
    16. Herbal nano-formulations for topical delivery Journal of Herbal Medicine · 2019 · 36 citations
    17. Topical agents used in association with cosmetic surgery Seminars in cutaneous medicine and surgery · 1999 · 13 citations
    18. Improvement of dermal and transdermal therapies by nanocarrier-based drug delivery Refubium (Universitätsbibliothek der Freien Universität Berlin) · 2018
    19. The role of PPAR<i>γ</i>-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology Experimental Dermatology · 2015 · 84 citations
    20. Phylogeny of the Hair Follicle: The Sebogenic Hypothesis Journal of Investigative Dermatology · 2007 · 21 citations
    21. The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions International Journal of Molecular Sciences · 2022 · 11 citations
    22. Molecular Dermatology Methods in molecular biology · 2026
    23. 피부장벽, 이온, 사이토카인 한국피부장벽학회지 · 2009
    24. 519 The role of the leaky gut in the development of alopecia areata 2019
    25. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    26. A finasteride patch for the treatment of androgenetic alopecia: A study of promoting permeability strategy using synthetic novel O-acylmenthols combined with ion-pair International Journal of Pharmaceutics · 2024
    27. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation The Journal of Cell Biology · 2001 · 195 citations
    28. Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood–Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats Nutrients · 2020 · 13 citations
    29. Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice Journal of Investigative Dermatology · 2003 · 216 citations
    30. Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure Langmuir · 2023 · 9 citations