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research Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors

10 citations , October 2018 in “Sexual medicine reviews”

This review discusses sexual side effects in men with androgenic alopecia treated with 5-alpha reductase inhibitors and reports no new clinical findings.

research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats

13 citations , December 2010 in “Pharmacology Biochemistry and Behavior”

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

research Central 5-alpha reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary–adrenal axis response to restraint stress in adult male rats

51 citations , July 2013 in “Brain Research”

Testosterone needs to be converted to DHT to reduce stress response in male rats.

Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase and 5-Alpha Reductase Inhibition

research Androgenic Efficacy and Mechanism of Glycosides-Based Standardized Fenugreek Seeds Extract Through Aromatase And 5-Alpha Reductase Inhibition

1 citations , February 2024 in “Pharmacognosy Journal”

In this study, fenugreek seed extract showed significant androgenic and spermatogenic effects in male rats, likely through inhibiting testosterone metabolism, without impacting cardiovascular health.

research Inhibition of skin 5α-reductase by oral contraceptive progestinsin vitro

78 citations , January 2000 in “Gynecological Endocrinology”

This study found that the progestins norgestimate and dienogest may help treat clinical hyperandrogeny in women by inhibiting skin 5 alpha-reductase activity with minimal androgenic potential.

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community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 year ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

116 upvotes 1 year ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community What can be the real reason of Finasteride SE ?

18 upvotes 1 year ago

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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learn Stem Cell Factor

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

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