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Glossary Perifollicular

area surrounding hair follicle

Perifollicular refers to the area surrounding a hair follicle. In medical and dermatological contexts, this term is often used to describe conditions or observations, such as inflammation or fibrosis, that occur around the hair follicles. For example, perifollicular inflammation is a common feature in certain types of hair loss, like alopecia areata, where the immune system attacks the hair follicles.

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Research

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research Perifollicular erythema as a trichoscopy sign of progression in frontal fibrosing alopecia

40 citations , January 2013 in “International journal of trichology”

This study found that among women with frontal fibrosing alopecia, 100% showed dermoscopic elements suggestive of the condition, with perifollicular erythema often indicating disease activity.

research Histological features of peripilar signs associated with androgenetic alopecia

95 citations , January 2004 in “Archives of Dermatological Research”

This study found that peripilar signs on the scalp are linked to perifollicular lymphocytic infiltrates in early androgenetic alopecia, detectable even in areas with high hair density.

research Trichoscopic Signs in Dermatomyositis, Systemic Lupus Erythematosus, and Systemic Sclerosis: A Comparative Study of 150 Patients

12 citations , December 2021 in “Dermatology”

This study found that trichoscopy can differentiate between dermatomyositis, systemic lupus erythematosus, and systemic sclerosis by identifying distinctive features and may help assess disease activity.

research Peripilar Sign in Androgenetic Alopecia: Does It Really Indicate Peripilar Infiltrate?

January 2024 in “Dermatology practical & conceptual”

In this study, researchers found that the peripilar sign in patients with androgenetic alopecia does not indicate perifollicular infiltrate but is more frequent in individuals with lighter skin types due to contrast with the skin.

research It's not all traction: the pseudo ‘fringe sign’ in frontal fibrosing alopecia

39 citations , July 2015 in “British Journal of Dermatology”

This article discusses the pseudo 'fringe sign' in frontal fibrosing alopecia, highlighting that it is not solely related to traction, and it reports no new clinical results.

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Community Join

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

11 upvotes 2 years ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Dutasteride has been nuking me

in Finasteride/Dutasteride 156 upvotes 9 months ago

The user experienced significant hair loss after 9 months of using 0.5mg dutasteride and oral minoxidil, possibly due to alopecia areata. It is advised to consult a doctor for accurate diagnosis and treatment, as dutasteride and finasteride may not be effective.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community I Recovered From Severe Hair Loss: My 8-Month Regrowth Recovery — Full Timeline, Photos & Treatment Data

35 upvotes 4 months ago

A 29-year-old male experienced significant hair regrowth over 8 months using a protocol of oral Minoxidil, Dutasteride, Pyrithione Zinc Shampoo, and peptides GHK-CU, BPC-157, and TB-500. The treatment led to improved scalp coverage, reduced hair loss, and thicker hair, although results may vary for others.

community Why does the same hormone grow your beard and destroy your hairline?

44 upvotes 4 months ago

DHT promotes beard growth but causes scalp hair loss due to inflammation and fibrosis. Treatments like finasteride and minoxidil help with hormonal signals and blood flow but don't address underlying inflammation.

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