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GlossaryPerifollicular Inflammation

swelling and irritation around hair follicles

Perifollicular inflammation refers to the swelling and irritation that occurs around hair follicles. This condition can lead to hair loss and is often seen in various types of alopecia, such as alopecia areata. It involves immune cells attacking the hair follicles, which can disrupt normal hair growth and cause damage to the follicle structure.

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research It's Not All Traction: The Pseudo 'Fringe Sign' in Frontal Fibrosing Alopecia

39 citations, July 2015 in “British Journal of Dermatology”

The pseudo 'fringe sign' can also appear in frontal fibrosing alopecia, not just in traction alopecia, showing that this condition may be more common than thought.

research A New Histologic Pattern in 6 Biopsies From Early Frontal Fibrosing Alopecia

7 citations, August 2018 in “The American Journal of Dermatopathology”

Researchers found a new early sign of Frontal Fibrosing Alopecia that could help avoid misdiagnosis.

research Dermatoscopic Features of Central Centrifugal Cicatricial Alopecia

64 citations, June 2014 in “Journal of The American Academy of Dermatology”

Researchers found a white halo around hair in most patients with a specific type of hair loss, which helps in early diagnosis and treatment.

research Lichen Planopilaris in Women: A Retrospective Review at Mayo Clinic (1992-2016)

13 citations, August 2020 in “Mayo Clinic proceedings”

Women with lichen planopilaris often have thyroid disease, depression, anxiety, and may respond to treatment with slowed disease progression.

research Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp

19 citations, January 2015 in “Skin appendage disorders”

The report found a new type of hair loss in African-American women that affects more areas of the scalp than previously thought.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 7 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Novel effect of sildenafil (cialis) on hair growth

in Research/Science 21 upvotes 2 years ago

Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

community Does 0.5 mg of finasteride reduce SCALP DHT the same as 1 mg?

in Finasteride/Dutasteride 15 upvotes 5 months ago

The conversation is about whether 0.5 mg of finasteride reduces scalp DHT as effectively as 1 mg. Users suggest that even lower doses like 0.05 mg can significantly reduce scalp DHT.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

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