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GlossaryPerifollicular Inflammation

swelling and irritation around hair follicles

Perifollicular inflammation refers to the swelling and irritation that occurs around hair follicles. This condition can lead to hair loss and is often seen in various types of alopecia, such as alopecia areata. It involves immune cells attacking the hair follicles, which can disrupt normal hair growth and cause damage to the follicle structure.

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research It's Not All Traction: The Pseudo 'Fringe Sign' in Frontal Fibrosing Alopecia

39 citations , July 2015 in “British Journal of Dermatology”

The pseudo 'fringe sign' can also appear in frontal fibrosing alopecia, not just in traction alopecia, showing that this condition may be more common than thought.

research Alopecic Patches on the Extremities of a Young Man

February 2026 in “JEADV Clinical Practice”

Lichen planopilaris can cause hair loss on limbs, not just the scalp.

research A New Histologic Pattern in 6 Biopsies From Early Frontal Fibrosing Alopecia

7 citations , August 2018 in “The American Journal of Dermatopathology”

Researchers found a new early sign of Frontal Fibrosing Alopecia that could help avoid misdiagnosis.

research Frontal Fibrosing Alopecia Involving the Limbs Shows Inflammatory Pattern on Histology: A Review of 13 Cases

7 citations , August 2019 in “American Journal of Dermatopathology”

Frontal fibrosing alopecia on limbs shows permanent inflammatory hair loss, not typical scarring.

research Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp

19 citations , January 2015 in “Skin appendage disorders”

The report found a new type of hair loss in African-American women that affects more areas of the scalp than previously thought.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 3 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Novel effect of sildenafil (cialis) on hair growth

in Research/Science 18 upvotes 3 years ago

Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

community I just want to say Ru58841 saved my life.

in Chat 27 upvotes 2 years ago

A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 210 upvotes 1 year ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

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