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GlossaryPerifollicular Hyperpigmentation

darkening of skin around hair follicles due to inflammation

Perifollicular hyperpigmentation refers to the darkening of the skin around hair follicles. This condition often occurs due to inflammation or irritation, such as from acne, folliculitis, or certain hair removal methods, leading to an increased production of melanin in the affected areas.

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research A Prospective Study of Dermoscopic and Ultrastructural Features of Vitiligo-Associated Leukotrichia

December 2023 in “Clinical, cosmetic and investigational dermatology”

The study found that white hair in vitiligo has specific patterns and structures, which vary with the stage of the disease and may be similar to another hair condition.

research Segmental Vitiligo with Confetti-Like Peripheral Depigmentation

December 2018 in “European Journal of Pediatric Dermatology/PD. European journal of pediatric dermatology”

Segmental vitiligo affects hair follicle melanocytes, causing small, uniform depigmented spots.

research A New Assessment Method of Vitiligo by Combination of Dermoscopy and Reflectance Confocal Microscopy

December 2023 in “Clinical, cosmetic and investigational dermatology”

The new method combining dermoscopy and Reflectance Confocal Microscopy is more effective for evaluating vitiligo.

research Vitiligo-Like Depigmentation With Perifollicular Pigment Retention in Systemic Sclerosis Treated Successfully With Suplatast Tosilate

5 citations, January 2016 in “European Journal of Dermatology”

Suplatast tosilate successfully treated a woman's systemic sclerosis symptoms.

research Clinicopathologic Lessons in Distinguishing Cicatricial Alopecia: 7 Cases of Lichen Planopilaris Misdiagnosed as Discoid Lupus

15 citations, September 2014 in “Journal of The American Academy of Dermatology”

Seven patients were misdiagnosed with discoid lupus instead of lichen planopilaris due to similar symptoms, showing the need for careful diagnosis in scarring hair loss conditions.

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 13 upvotes 10 months ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Novel effect of sildenafil (cialis) on hair growth

in Research/Science 21 upvotes 2 years ago

Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

community Does 0.5 mg of finasteride reduce SCALP DHT the same as 1 mg?

in Finasteride/Dutasteride 15 upvotes 9 months ago

The conversation is about whether 0.5 mg of finasteride reduces scalp DHT as effectively as 1 mg. Users suggest that even lower doses like 0.05 mg can significantly reduce scalp DHT.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

in Research/Science 130 upvotes 2 weeks ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

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