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GlossaryPerifollicular

area surrounding hair follicle

Perifollicular refers to the area surrounding a hair follicle. In medical and dermatological contexts, this term is often used to describe conditions or observations, such as inflammation or fibrosis, that occur around the hair follicles. For example, perifollicular inflammation is a common feature in certain types of hair loss, like alopecia areata, where the immune system attacks the hair follicles.

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research Induction of Ornithine Decarboxylase in Specific Subpopulations of Murine Epidermal Cells Following Multiple Exposures to 12-O-Tetradecanoylphorbol-13-Acetate, Mezerein, and Ethyl Phenylpropriolate

26 citations , January 1992 in “Carcinogenesis”

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

research Eosinophilic Pustular Folliculitis Involving Labial Mucosa, Which Improved with Naproxen

1 citations , January 2013 in “Annals of Dermatology”

Naproxen effectively treated a girl's eosinophilic pustular folliculitis when other treatments failed.

research Apremilast and Tofacitinib Exert Differential Effects in the Humanized Mouse Model of Alopecia Areata

5 citations , June 2019 in “British Journal of Dermatology”

Tofacitinib was more effective than apremilast in treating hair loss in a mouse model of alopecia areata.

research Lichen Planopilaris: A Rare Inflammatory Cicatricial Alopecia

April 2012 in “Informa Healthcare eBooks”

Lichen planopilaris is a rare, chronic condition causing hair loss, mainly in middle-aged women, and early treatment is important to prevent permanent baldness.

research Hair and Scalp Manifestations in Secondary Syphilis: Epidemiology, Clinical Features and Trichoscopy

45 citations , January 2015 in “Dermatology”

Hair loss in secondary syphilis is more common than thought and can be reversed with antibiotics.

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community can someone help me identify these pls

in Treatment 3 months ago

The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community I just want to say Ru58841 saved my life.

in Chat 28 upvotes 2 years ago

A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

community 21M Concerned About Temple Recession: Minoxidil/Finasteride Worth It?

in General 203 upvotes 2 months ago

A 21-year-old is experiencing hair loss and is considering using Minoxidil and Finasteride, but is concerned about lifelong dependency and seeks advice on permanent solutions. They are advised to act quickly, consider additional treatments like Dutasteride, and get blood tests to rule out other causes.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 120 upvotes 4 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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