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GlossaryPerifollicular

area surrounding hair follicle

Perifollicular refers to the area surrounding a hair follicle. In medical and dermatological contexts, this term is often used to describe conditions or observations, such as inflammation or fibrosis, that occur around the hair follicles. For example, perifollicular inflammation is a common feature in certain types of hair loss, like alopecia areata, where the immune system attacks the hair follicles.

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research Induction of Ornithine Decarboxylase in Specific Subpopulations of Murine Epidermal Cells Following Multiple Exposures to 12-O-Tetradecanoylphorbol-13-Acetate, Mezerein, and Ethyl Phenylpropriolate

26 citations, January 1992 in “Carcinogenesis”

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

research Eosinophilic Pustular Folliculitis Involving Labial Mucosa, Which Improved with Naproxen

1 citations, January 2013 in “Annals of Dermatology”

Naproxen effectively treated a girl's eosinophilic pustular folliculitis when other treatments failed.

research Apremilast and Tofacitinib Exert Differential Effects in the Humanized Mouse Model of Alopecia Areata

5 citations, June 2019 in “British Journal of Dermatology”

Tofacitinib was more effective than apremilast in treating hair loss in a mouse model of alopecia areata.

research Lichen Planopilaris: A Rare Inflammatory Cicatricial Alopecia

April 2012 in “Informa Healthcare eBooks”

Lichen planopilaris is a rare, chronic condition causing hair loss, mainly in middle-aged women, and early treatment is important to prevent permanent baldness.

research Hair and Scalp Manifestations in Secondary Syphilis: Epidemiology, Clinical Features and Trichoscopy

45 citations, January 2015 in “Dermatology”

Hair loss in secondary syphilis is more common than thought and can be reversed with antibiotics.

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community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 4 months ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community I just want to say Ru58841 saved my life.

in Chat 28 upvotes 2 years ago

A user's experience with hair loss and scalp inflammation, which was alleviated by using RU58841 along with finasteride and dutasteride. A theory of inflammation possibly being a cause of hairloss is also discussed.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 7 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 374 upvotes 2 days ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 8 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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