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research Effect of PEG 400 concentration on the physicochemical characteristics and stability of Persea americana seed oil nanoemulsion hair spray

August 2026 in “Pharmacy Reports”

This study found that a nanoemulsion hair spray formula with 25% PEG 400 showed promising physicochemical stability, but further research is needed to assess its colloidal stability and efficacy in hair growth.

Effect of Tocopheryl Polyethylene Glycol Succinate on the Percutaneous Penetration of Minoxidil from Water/Ethanol/Polyethylene Glycol 400 Solutions

research Effect of Tocopheryl Polyethylene Glycol Succinate on the Percutaneous Penetration of Minoxidil from Water/Ethanol/Polyethylene Glycol 400 Solutions

11 citations , January 2006 in “Drug development and industrial pharmacy”

In this study, adding TPGS to a minoxidil formulation improved local retention and reduced systemic absorption in certain solvent mixes, particularly with a balance of alcohol and PEG 400.

research Ex vivo permeation parameters and skin deposition of melatonin-loaded microemulsion for treatment of alopecia

4 citations , May 2022 in “Future Journal of Pharmaceutical Sciences”

This study found that a melatonin-loaded microemulsion exhibited controlled release and significant stratum corneum deposition in ex vivo permeation tests, suggesting its potential for further evaluation in treating androgenic alopecia.

research Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles

19 citations , January 2020 in “Journal of Biophotonics”

This study found that using a PEG-400/oleic acid mixture as an optical clearing agent enhanced the detection depth of particles in skin without causing dehydration, based on tests in rats and further testing in vivo.

research Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management

16 citations , January 2023 in “Acta Biomaterialia”

This study reported that a new bioinspired injectable hydrogel, CQCS@gel, showed promise as a multifunctional wound dressing by achieving rapid hemostasis and promoting the healing of infected skin wounds in both in vitro and in vivo tests.

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community Has anyone had experience with mixing ky19382 with Peg400 or other mixtures?

2 upvotes 2 months ago

The conversation discusses experiences with mixing KY19382 with PEG400 or other mixtures for hair loss treatment. It also mentions interest in a group purchase of KY19382 or other hair loss research powders.

community Be careful about using non-PG based alternatives of Minoxidil (mathematically speaking, haven’t seen much practical studies)

in Research/Science 7 upvotes 1 month ago

Minoxidil formulations often use propylene glycol (PG) for stability and effectiveness, but PG-free alternatives like foams and PEG-based solutions can also be effective with less irritation. Concerns exist about the quality of PG-free minoxidil from lesser-known brands, especially from India, due to potential manufacturing issues.

community Possible natural pp405 solution

in Research/Science 45 upvotes 1 year ago

Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

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