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GlossaryPhosphodiesterase Inhibitors (PDEIs)

block enzymes that break down cyclic nucleotides

Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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research Phosphodiesterase Inhibitors and Prostaglandin Analogues in Dermatology: A Comprehensive Review

9 citations, December 2020 in “Dermatologic Therapy”

Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.

research Lower Urinary Tract Symptoms: What’s New in Medical Treatment?

22 citations, January 2018 in “European urology focus”

New drugs and combination therapies are improving treatment for lower urinary tract symptoms.

research Comment on ‘Androgenetic Alopecia Is Associated with Increased Scalp Hardness’: Role of Phosphodiesterase Inhibitors?

1 citations, April 2020 in “Journal of The European Academy of Dermatology and Venereology”

Drugs like PDEI may help hair disorders like AGA.

research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations, July 2016 in “Urologic Clinics of North America”

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

research The Use of Phosphodiesterase Inhibitors for the Treatment of Alopecia

3 citations, April 2019 in “Journal of Dermatological Treatment”

Caffeine shows promise for treating some types of hair loss, but more research is needed.

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community Help in Germany to get recommended medicine

in Finasteride/Dutasteride 5 upvotes 4 months ago

A user in Germany is seeking advice on obtaining Dutasteride, Minoxidil, and Biotin for hair treatment before a hair transplant. They face difficulties getting prescriptions and are concerned about delays due to required exams.

community 39m 1.1mg finasteride 3mg oral minoxidil

in Progress Pictures 17 upvotes 9 months ago

A user shared their progress using 1.1mg oral finasteride and 3mg oral minoxidil since January 2024, noting significant improvement without side effects. They previously had an allergic reaction to topical treatments.

community Hair energiser tablets, useful or not?

in Product 8 months ago

A user is unsure if "Hair Energiser" tablets are effective for hair growth after a year of use. Replies suggest using finasteride instead and call the tablets a scam.

community Soon nearly 2 Years Finasteride+Minoxidil Update

in Progress Pictures 406 upvotes 10 months ago

The conversation is about a user sharing a nearly 2-year update on hair regrowth using finasteride and minoxidil, with occasional use of microneedling. Commenters are impressed with the significant improvement in the user's hair.

community I am finally giving up on my hair

in Shaved/buzzed 57 upvotes 1 year ago

User tried Minoxidil and Finasteride for hair loss with no success and considers giving up. Others suggest continuing treatment, trying hair transplant, or embracing baldness.