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research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.

research Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development

7 citations , October 2022 in “Development”

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

research Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse

92 citations , April 2009 in “Journal of Investigative Dermatology”

The Celsr1 gene is crucial for normal hair patterning in mice.

research Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia

19 citations , August 2012 in “Cell death and differentiation”

This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

research 851 The role of astrotactin2 in regulating mammalian skin polarity

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.

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community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community TRUST THE PROCESS! Glad I stuck with it. Hope it gives more hope to others.

1987 upvotes 7 months ago

Significant hair regrowth was achieved after 8 months on oral finasteride (1mg) and 5 months on oral minoxidil (5mg) without side effects. The user stressed the importance of patience and consistency, despite initial shedding.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 1 year ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

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