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GlossaryHand-Foot Syndrome (Palmar-Plantar Erythrodysesthesia)

causes redness, swelling, and pain on palms and soles

Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

1461 citations, March 2004 in “Annals of oncology”

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

research Development of PEGylated Liposomes

October 2011

PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.

Chemotherapy-Induced Dermatological Toxicity: Frequencies and Impact on Quality of Life in Women’s Cancers. Results of a Prospective Study

research Chemotherapy-Induced Dermatological Toxicity: Frequencies and Impact on Quality of Life in Women’s Cancers. Results of a Prospective Study

76 citations, August 2007 in “Supportive care in cancer”

Chemotherapy often causes skin, nail, and hair side effects, significantly impacting quality of life.

research Cutaneous Toxicities of New Targeted Cancer Therapies: Must Know for Diagnosis, Management, and Patient-Proxy Empowerment

7 citations, October 2019 in “Annals of palliative medicine”

New targeted cancer drugs can cause skin side effects, and managing them requires patient education and timely care.

research Pathogenesis of Hand-Foot Syndrome Induced by PEG-Modified Liposomal Doxorubicin

63 citations, February 2013 in “Human cell”

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.

View more "palmar-plantar erythrodysesthesia" in research →

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community Normalize hair systems for men! If females can get extensions and wear makeup it should be socially acceptable for men to wear a hair piece

in Hair Systems 1043 upvotes 1 month ago

Men should feel socially accepted wearing hair systems, similar to how women use extensions and makeup. Treatments mentioned include minoxidil, finasteride, and hair transplants.

community How to BECOME a RESPONDER to Fin/Dut if you are not responding

in Finasteride/Dutasteride 308 upvotes 1 year ago

The conclusion of this conversation is that the user "DuckSeasonCamelSeasn" found that consuming grapefruit juice prior to taking finasteride or dutasteride helped them become a responder to the medications and regain hair growth. However, there are warnings about potential risks and interactions with other medications, so caution should be exercised.