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Research

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research Increase in testosterone metabolism in the rat central nervous system by formalin-induced tonic pain

11 citations , October 2002 in “Pharmacology Biochemistry and Behavior”

This study found that formalin-induced pain in rats nearly eliminates testosterone in the brain and spinal cord by likely increasing 5α-reductase activity, but normalizes serum levels after 24 hours.

research Hormone replacement therapy in morphine-induced hypogonadic male chronic pain patients

74 citations , January 2011 in “Reproductive Biology and Endocrinology”

This study suggests testosterone gel administered for one year to male chronic pain patients receiving morphine may improve sexual function and mental health, despite limited effects on overall pain scores.

research Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats

13 citations , December 2010 in “Pharmacology Biochemistry and Behavior”

Inhibiting certain enzymes made female rats more sensitive to low-level pain.

research Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice

2 citations , September 2024 in “Pharmaceuticals”

This study suggests that human placenta hydrolysate reduces CFA-induced inflammatory pain in mice by inhibiting pro-inflammatory cytokines and protecting peripheral nerves.

research Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain

50 citations , May 2019 in “Drugs”

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

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Community Join

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community Anyone Else Get Scalp Pain and Hair Loss on Creatine?

4 upvotes 1 year ago

Creatine may trigger hair loss and scalp pain, possibly due to increased DHT levels, as experienced by several users. Some users found stopping creatine and finasteride improved their symptoms.

community If pp405 isnt the “cure” is there anything else that’s promising thats atleast better than min or dut?

20 upvotes 5 months ago

Hair cloning and new treatments like ET-02, Veradermics (vdphl01), and wound-induced hair neogenesis show promise but are not yet widely available. Current effective treatments include minoxidil, finasteride, and dutasteride, with early intervention being crucial for better outcomes.

community Extreme caution: my experience using Ru58841 only once

in Treatment 10 upvotes 1 year ago

An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

community What else to add to my stack? All help extremely appreciated!

7 upvotes 4 years ago

The user is using a hair loss treatment regimen including Avodart (dutasteride), oral minoxidil, LLLT caps, vitamins, and ketoconazole shampoo, and is considering adding dermarolling and RU58841. They are experiencing unwanted body hair growth from minoxidil and are planning for a future hair transplant.

community 5 Months on topical Fin/Min progress: grows hair and boobs

in Progress Pictures 159 upvotes 11 months ago

The user experienced significant hair growth using topical finasteride and minoxidil but noticed nipple changes, suggesting early gynecomastia. They plan to stop the treatment and consider blood work to check hormonal balance.

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Learn

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learn Peppermint

herb and oil thought to stimulate skin and hair

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Overview

learn Hair Transplant

How much pain will I be in after a hair transplant surgery? Pain after a hair transplant is usually mild to moderate and manageable with medication.
Will I feel pain during a hair transplant? Most patients feel minimal discomfort during a hair transplant due to local anesthesia.
How long does pain last after a hair transplant? Mild discomfort after a hair transplant typically lasts a few days to a week.
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learn Scalp Micropigmentation

Will I experience pain after the scalp micropigmentation treatment? You may feel discomfort during the procedure and soreness afterward.

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