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Research

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research Somatosensory organization and behavior in naked mole‐rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain

101 citations , August 2003 in “Journal of comparative neurology”

In this study, naked mole-rats demonstrated unique skin and hair follicle innervation features compared to other species, suggesting adaptations to their subterranean environment and poikilothermy.

research Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

61 citations , September 2011 in “Pain”

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

research Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation

42 citations , June 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that PAI-2 is consistently expressed in differentiating cells of murine hair and nail, suggesting it may function as a marker of differentiation and possibly protect against premature cell death.

Multiple Crosslinked, Self-Healing, and Shape-Adaptable Hydrogel Laden with Pain-Relieving Chitosan@Borneol Nanoparticles for Infected Burn Wound Healing

research Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing

37 citations , December 2024 in “Theranostics”

In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.

research Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes

35 citations , January 2022 in “Frontiers in Neurology”

This review utilizes clinical vignettes to detail various pain syndromes associated with multiple sclerosis, including their pathophysiology and management strategies, highlighting conditions like central neuropathic pain, Lhermitte's phenomenon, and trigeminal neuralgia as they relate to different lesion types.

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Community Join

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community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community Anyone notice pain in scalp alongside hairloss?

10 upvotes 1 month ago

Scalp pain alongside hair loss may indicate inflammation rather than just male pattern baldness. Treatments mentioned include triamcinolone acetonide, fluocinonide, Head & Shoulders shampoo, aloe vera gel, finasteride, and 2% Nizoral.

community Creatine paired with finasteride

1 month ago

Creatine does not cause hair loss, and taking finasteride three times a week is more impactful for hair retention. Consistent use of treatments like finasteride, minoxidil, and other hair care products is recommended for managing hair loss.

community Creatine paired with Finasteride

22 upvotes 1 year ago

Finasteride and creatine are discussed for hair loss, with mixed opinions on creatine's impact. Some users report no hair loss with creatine, while others experience shedding, but finasteride is generally seen as effective.

community Testicular pain/discomfort....how long will this last? (29/m)

5 upvotes 9 years ago

A user experienced testicular pain after taking finasteride for hair loss and considered lowering the dose to 0.25mg to manage side effects. They also considered adding minoxidil to their routine while seeking advice on whether to continue or stop finasteride.

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Learn

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learn Hair Transplant

How much pain will I be in after a hair transplant surgery? Pain after a hair transplant is usually mild to moderate and manageable with medication.
Is a hair transplant painful? A hair transplant is generally comfortable due to local anesthesia, with mild post-procedure soreness possible.

learn procapil

Could pairing Procapil with antioxidants be the power combo for stress-induced hair thinning? Procapil combined with antioxidants may effectively combat stress-induced hair thinning.

learn Scalp Micropigmentation

Can I take painkillers before my scalp micropigmentation session? Most providers suggest paracetamol about an hour before an SMP session and caution against aspirin, while their advice on ibuprofen is split. Ask a doctor or pharmacist first, and never stop a prescribed blood thinner for a cosmetic appointment.
Will I experience pain after the scalp micropigmentation treatment? You may feel discomfort during the procedure and soreness afterward.