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In this study, naked mole-rats demonstrated unique skin and hair follicle innervation features compared to other species, suggesting adaptations to their subterranean environment and poikilothermy.

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

This study observed that PAI-2 is consistently expressed in differentiating cells of murine hair and nail, suggesting it may function as a marker of differentiation and possibly protect against premature cell death.

In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.

This review utilizes clinical vignettes to detail various pain syndromes associated with multiple sclerosis, including their pathophysiology and management strategies, highlighting conditions like central neuropathic pain, Lhermitte's phenomenon, and trigeminal neuralgia as they relate to different lesion types.

This study suggests that IV delivery of ExoFlo may be a safe and effective treatment for addressing symptoms in CRPS patients, warranting further investigation.

This report introduces a new potential sign, paired ear creases of the helix, which may have relevance to cardiovascular disease similar to diagonal ear lobe creases, in a case of coronary artery disease.

This study found that adults with trichotillomania did not show differences in pain tolerance or exhibit analgesia to cold pressor pain compared to healthy controls.

This review discusses pain management strategies for optical permanent hair removal, which causes pain due to the increase in skin surface temperature, but reports no new experimental results.

This study found that greater root surface area due to root hairs contributed to better growth and zinc uptake of wild-type barley compared to its root-hairless mutant in zinc-deficient soil.

This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.

This case report described how peripheral nerve stimulation provided significant pain relief and reversal of dermatological symptoms for a female patient with complex regional pain syndrome after conventional treatments failed.

Using a handheld massage device during hair transplant significantly reduces pain for most patients.

In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.

Vibration anesthesia can significantly lessen the pain during hair restoration surgery.

This report describes a rare case of painless thyroiditis induced by prolonged off-label use of Lugol’s solution in a 59-year-old woman.

This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.

This study explored the intersection of art and medicine, specifically examining the depiction of the malar rash associated with lupus in historical paintings. The authors suggest that this approach, known as iconodiagnosis, can enhance medical education and understanding of disease manifestations through visual arts.

This retrospective study found that applying local skin precooling before scalp nerve block significantly reduced injection site pain during PRP mesotherapy for patients with androgenetic alopecia, compared to those who did not receive precooling, thus improving patient comfort and compliance.

In this report, a rare case of gynecomastia was observed in a 76-year-old man using 0.25% topical finasteride for hair loss, with breast tenderness resolving after stopping treatment but persistent enlargement.

This study reports that oxytocin receptor expression in keratinocytes shows a potential relationship with touch sensory neurons, suggesting a role in skin sensitivity and the broader function of sensory neurons.

This study demonstrated that the Epidermal Biopotential Sensing System (EBSS) can measure digital biomarkers of pain in mice, suggesting potential applications in assessing pain and screening analgesics in populations with communication difficulties.

This case study of a 45-year-old man from Tonga describes the identification of pachyonychia congenita through genetic testing, revealing a mutation in the keratin gene KRT16, associated with chronic painful skin and nail conditions.

This case report describes a man with trichorrhexis nodosa of the beard, who experienced symptomatic improvement after being advised to shave and avoid brushing, confirming the diagnosis.

Older adults may experience painful finger pitting due to nerve changes in aging skin, and treatments can help reduce symptoms.

This study found that keloids significantly impair quality of life, with pain and itch being major contributors to this impact, comparable to other chronic dermatologic conditions.

This case report documents successful virilization, including penile length increase, in a boy with partial androgen insensitivity syndrome using high-dose testosterone combined with anastrozole.

This article discusses the symptoms, diagnosis, and treatment of thallium poisoning, with no new clinical results reported; the authors emphasize the importance of early suspicion for effective intervention.

Itch is a common symptom in patients with chronic venous insufficiency, often accompanied by burning and pain.