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Glossary Osteopontin

protein aiding bone remodeling and immune regulation

Osteopontin is a protein found in the body that plays a crucial role in bone remodeling and immune system regulation. It helps in the attachment of cells to the bone matrix and is involved in processes like inflammation and tissue repair, making it significant in both health and disease contexts.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

What role does Osteopontin play in protecting and repairing hair follicles? Osteopontin protects and repairs hair follicles by signaling cells to survive and recover.
Is Osteopontin more effective in topical treatments or oral supplements for hair loss? Neither route has been tested: there is no published human trial of topical or oral osteopontin for hair loss. The evidence is preclinical, and it points both ways — injected osteopontin promoted hair growth in mice, while an osteopontin-derived peptide suppressed growth in human scalp tissue and is being developed to remove unwanted hair.
How does Osteopontin support the scalp’s healing and reduce inflammation? Osteopontin aids scalp healing by attracting immune cells and promoting growth factors.
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Research

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research Basal Cell Carcinoma With Matrical Differentiation: Expression of .-catenin and Osteopontin

26 citations , October 2007 in “American Journal of Dermatopathology”

This study observed that basal cell carcinomas with matrical differentiation may derive from hair follicles, with .-catenin potentially playing a key role in tumor development and differentiation.

research An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

19 citations , September 2019 in “British Journal of Dermatology”

This study found that a novel peptide, FOL-005, derived from osteopontin, significantly inhibited hair growth in human hair follicles both ex vivo and in vivo, suggesting potential as a treatment for unwanted hair growth.

research Osteopontin Gene is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner

17 citations , December 2001 in “Journal of Investigative Dermatology”

This study found that osteopontin mRNA is abundantly expressed in dermal papilla cells during the catagen phase of hair growth in rats, suggesting a role in this phase.

research Osteopontin: a new facilitating factor in alopecia areata pathogenesis?

7 citations , January 2015 in “PubMed”

This study found that patients with alopecia areata had higher plasma osteopontin levels compared to healthy controls, but complete recovery after DPCP treatment did not significantly reduce these levels.

research Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

5 citations , June 2024 in “Pharmacological Research”

This study identified neuropilin-1 as the receptor for FOL-026 and showed that it stimulates angiogenesis and cell growth, suggesting potential for vascular repair and enhanced angiogenesis therapies.

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community Published in Nature: Osteopontin, a protein involved in the growth of hair on moles could be the key to our troubles.

13 upvotes 3 years ago

Osteopontin, a protein involved in hair growth on moles, may help with hair loss. However, it is also linked to Alzheimer's, cancer, and bone development, so caution is advised.

community Amplifica and AMP-303 clinical phase 1

9 upvotes 2 years ago

Amplifica is testing a compound called AMP-303 for hair loss, but it's not Scube3 or osteopontin. The timing for the results from the clinical trial is unknown.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 4 weeks ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

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