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research Open-label placebos reduce hair cortisol concentrations and psychological distress - a randomized controlled trial

June 2026 in “Scientific Reports”

In this study, university students given open-label placebo treatment reported reduced psychological distress and lower hair cortisol concentrations during stressful exams, suggesting that these placebos may help manage the physiological and psychological impacts of prolonged stress.

research Integrated Safety Analysis of Ritlecitinib in Adolescent Patients with Alopecia Areata from the Randomized, Placebo-Controlled ALLEGRO Phase 2b/3 and Ongoing Open-Label Phase 3 ALLEGRO-LT Studies

1 citations , November 2023 in “SKIN The Journal of Cutaneous Medicine”

research Safety and Efficacy of an Oral Nutraceutical Supplement Gummy and Peptide Serum in Promoting Hair Growth: Initial Results of A Randomized Placebo Controlled Trial with an Open Label Extension

May 2026 in “SKIN The Journal of Cutaneous Medicine”

This study suggests that a proprietary nutraceutical supplement gummy and peptide serum regimen may be safe and effective for improving hair growth and density in females with pattern hair loss.

research 455 Molecular correlation with clinical outcomes in an open label clinical trial of oral tofacitinib in patients with alopecia areata

1 citations , April 2018 in “Journal of Investigative Dermatology”

This open-label study found that oral tofacitinib led to significant hair regrowth in patients with moderate-to-severe alopecia areata, supported by changes in gene expression and T cell dynamics.

research An Open-label Experience Trial to Evaluate the Effects of a Novel Supplement and Hair Serum Combination on Hair, Skin and Nails in Healthy Women

June 2021 in “Current developments in nutrition”

In this open-label study, participants reported that the LustrivaTM BH-002 two-step system improved various aspects of hair, skin, and nail health and appearance after three months of use.

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Community Join

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community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 30 upvotes 6 months ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026

1080 upvotes 6 months ago

PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.

community Before and after PP405 from phase 2a after applying it for just 4 weeks

in Chat 279 upvotes 6 months ago

PP405 shows some hair growth after 4 weeks, but results are debated and expectations should be tempered. Some users compare it to minoxidil or finasteride, questioning its effectiveness and commercialization timeline.

community KX-826+Minoxidil Outperforms Minoxidil Alone for AGA Treatment: 30+ New Hairs/cm² (24 Weeks, P=0.0075)

38 upvotes 1 year ago

KX-826 combined with minoxidil significantly increases hair growth compared to minoxidil alone for treating male androgenetic alopecia, with no unexpected safety concerns. Users discuss various hair loss treatments, including KX-826, minoxidil, finasteride, and RU58841, sharing personal experiences and sourcing information.

community People are misunderstanding PP405. 31% response at 8 weeks is better than you think

181 upvotes 1 year ago

PP405 shows promise as a hair loss treatment, with 31% experiencing increased hair density in a short trial. It may complement treatments like finasteride and minoxidil, but long-term effectiveness and safety need confirmation.

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Learn

7 / 7 results

learn Botox

How does Botox target the tension that may be blocking your hair growth? Botox for hair loss is experimental and off-label: one small open-label pilot study of 50 men reported an 18% hair-count increase, but there is no placebo-controlled trial and the proposed scalp blood-flow mechanism has never been measured in patients.

learn Latanoprost

Prostaglandin eye drop used for glaucoma

learn HMI-115

Experimental antibody that blocks the prolactin receptor

learn Pyrilutamide

Experimental topical anti-androgen, also known as KX-826

learn Caffeine

Does caffeine stimulate hair growth or only slow hair loss? Caffeine stimulates hair follicles in laboratory cultures, and one open-label, manufacturer-funded trial in 210 men found a 0.2% caffeine topical non-inferior to minoxidil 5% on an anagen-ratio endpoint. A 2025 systematic review found only a few small controlled trials, mostly rated low or very low quality, and none in alopecia areata.

learn Saw Palmetto

Is saw palmetto as effective as finasteride against DHT? In the only head-to-head hair study, which was open-label, fewer men improved on saw palmetto (38%) than on finasteride (68%). That study did not measure DHT levels.

learn Tofacitinib

What types of hair loss conditions are most commonly associated with tofacitinib use in clinical settings? Published studies link tofacitinib mainly to alopecia areata and its severe variants — as an off-label drug being studied for them, not as a cause of hair loss. The evidence is mostly small, open-label or retrospective, and relapse after stopping is commonly reported.

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