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GlossaryGlucocorticoid Receptor (NR3C1 Protein)

regulates gene expression by binding to glucocorticoid hormones

The Glucocorticoid Receptor (GR) is a type of protein found inside cells that binds to glucocorticoids, which are a class of steroid hormones. When these hormones bind to the receptor, it can influence the expression of specific genes, thereby regulating processes like inflammation, immune response, and metabolism. This receptor is crucial in medical treatments for conditions like asthma, autoimmune diseases, and even certain types of hair loss, such as alopecia areata.

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research Involvement of the Central Hypothalamic-Pituitary-Adrenal Axis in Hair Growth and Melanogenesis Among Different Mouse Strains

6 citations , October 2018 in “PLoS ONE”

Stress can slow hair growth and affect skin color by impacting the body's stress response system.

research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

15 citations , April 2017 in “Hormones”

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

research The Glucocorticoid Resistance Syndrome: Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene

December 2023 in “JCEM case reports”

A new gene variant causes glucocorticoid resistance in a mother and son.

research Transcriptomics Identifies Potential Novel Therapeutic Targets in Androgenetic Alopecia

April 2017 in “Journal of Investigative Dermatology”

Found new possible treatments for hair loss.

research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management

47 citations , February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

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