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GlossaryGlucocorticoid Receptor (NR3C1 Protein)

regulates gene expression by binding to glucocorticoid hormones

The Glucocorticoid Receptor (GR) is a type of protein found inside cells that binds to glucocorticoids, which are a class of steroid hormones. When these hormones bind to the receptor, it can influence the expression of specific genes, thereby regulating processes like inflammation, immune response, and metabolism. This receptor is crucial in medical treatments for conditions like asthma, autoimmune diseases, and even certain types of hair loss, such as alopecia areata.

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research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

15 citations, July 2017 in “Hormones”

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.