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research 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa

2 citations , September 2017 in “Journal of Investigative Dermatology”

This study found that notch1 signaling is severely impaired in hidradenitis suppurativa patients with or without NCSTN or other gamma-secretase gene mutations, highlighting a canonical defect at the lesional tissue level.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

research Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways

May 2026 in “Scientific Reports”

In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.

research Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep

December 2025 in “Animals”

In this study on fine-wool sheep, researchers found that overexpressing the TGFBR1 gene decreased proliferation of dermal papilla cells by influencing multiple signaling pathways, suggesting TGFBR1 as a negative regulator in hair follicle development.

research Molecular biology of hair morphogenesis: Development and cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.

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community HT Update – 36 Days Post-Op (5500 Grafts, Delhi)

22 upvotes 1 year ago

A user shared their experience 36 days after a hair transplant of 5500 grafts in Delhi, using topical minoxidil and finasteride, and plans to start oral finasteride. They reported less shedding than expected and strong early growth, while also maintaining a healthy lifestyle.

community Crown Christmas Miracle: Back From the Dead 💀

2107 upvotes 8 months ago

A 42-year-old man achieved significant hair regrowth in seven months using oral minoxidil, oral dutasteride, topical minoxidil, microneedling, and supplements. He experienced minimal side effects and noted dramatic improvements in hair thickness and health.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community 4 months of 1mg of fin a day and 5 months of topical minoxidil

in Progress Pictures 1053 upvotes 9 months ago

Significant hair regrowth was achieved using 1mg of finasteride daily, 3ml of topical minoxidil, ketoconazole shampoo, vitamin D, and castor oil, with no side effects. Results appeared after two months, leading to discussions on treatment effectiveness and commitment.

community 1 year Monthly Progress (Top Minox, Oral Fin, Vitamin D, Dermastamp)

50 upvotes 2 months ago

The user shared progress pictures after one year of using topical Minoxidil, oral Finasteride, Vitamin D, and dermastamping for hair loss. Many suggest continuing treatment, considering a hair transplant, or switching to dutasteride for better results.

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