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research Spermidine/spermine-N¹-acetyltransferase: a key metabolic regulator

305 citations , March 2008 in “AJP Endocrinology and Metabolism”

This article reviews the regulation and roles of spermidine/spermine-N(1)-acetyltransferase (SSAT) in polyamine metabolism and its potential as a target in cancer and other diseases, without reporting new experimental results.

research Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

124 citations , July 1997 in “Journal of Biological Chemistry”

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

This study suggests that activation of polyamine catabolism in K6-SSAT transgenic mice may significantly increase skin tumor development and progression to carcinomas following chemical induction.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression

37 citations , February 2005 in “Journal of Investigative Dermatology”

This research suggests that defects in keratinocyte differentiation due to putrescine accumulation in SSAT transgenic mice lead to skin changes and hair loss, and reducing putrescine can promote hair regrowth.

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Community Join

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community Dutasteride and Sperm Volume concern

in Finasteride/Dutasteride 5 upvotes 5 months ago

Dutasteride can significantly reduce sperm volume, with some users experiencing up to a 90% decrease. While some users report adaptation over time, others suggest switching to finasteride if side effects are too severe.

community Spearmint tea for hair regrowth

3 upvotes 10 months ago

Spearmint tea and inositol are discussed as potential treatments for hair regrowth, but their effectiveness is questioned. Alternatives like green tea, MSM, and evening primrose oil are suggested for hair health.

community What do you think about drinking spearmint tea while on finasteride?

3 years ago

The user is concerned that drinking spearmint tea while on finasteride might harm sperm count, mobility, and testosterone levels, despite seeing positive effects on hair. They seek advice on whether to continue or stop the tea.

community H as anyone done sperm/fertility test before and after staring finasteride?

6 upvotes 6 years ago

The conversation discusses the impact of finasteride on sperm, including potential side effects like decreased ejaculate volume and total sperm count. Users share experiences and concerns about fertility tests before and after starting finasteride.

community Is it ok to supplement spearmint?

in Treatment 6 years ago

The conversation discusses the potential effects of spearmint on acne and male pattern baldness (MPB). Concerns are raised about spearmint's androgen-suppressing effects and its suitability for men.

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Learn

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learn spearmint

learn RU58841

RU58841: Is it safe or does it have strange side effects? (Because no one wants unpleasant surprises) There is no published human safety study of RU58841: the evidence is animal and tissue work only, human absorption has never been measured, and the side effects users describe are self-reported with unverified product.

learn Centella

Got small bald circles with no warning? Centella creams might calm the area and kickstart new growth. There is no published human trial of Centella asiatica for alopecia areata or any other hair loss; the only hair-related studies are cell-culture work. Community users describe Centella creams as soothing for an irritated scalp, not as regrowth treatments, and a new bald patch needs a doctor's diagnosis first.

learn Vitamin B5

Can a vitamin B5-rich hair mask rescue your strands when no shampoo seems to work? A vitamin B5-rich hair mask can improve hair health but won't replace shampoo.

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