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research Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5α-Reductase: Definition of a Selective Role for Dihydrotestosterone*

53 citations , January 1986 in “Endocrinology”

This rat study suggests that 5α-dihydrotestosterone plays a critical role in inhibiting nipple development in male fetuses by causing the regression of the nipple anlage in utero.

research Estrogen modulates mesenchymal-epidermal interactions in the adult nipple

4 citations , March 2017 in “Development”

This study found that specialized nipple epidermis in mice is maintained by the repression of TGFβ signaling through estrogen, which highlights the role of hormonal regulation in epidermal maintenance.

research Unilateral nevoid hyperkeratosis of the nipple and areola in a Saudi female

2 citations , July 2018 in “Our Dermatology Online”

This case report documents the first known instance of nevoid hyperkeratosis of the nipple and areola with unilateral presentation in a Saudi female, diagnosed through clinical evaluation and biopsy.

research Effects of Finasteride and DEHP on anogenital distance and nipple retention after perinatal exposure in rats

1 citations , January 2005 in “Research Portal (King's College London)”

Finasteride and DEHP exposure during development can change reproductive markers in rats.

research Depletion of S100A4+ stromal cells results in abnormal nipple development and nursing failure

January 2026

This study used a mouse model to reveal that S100A4-positive cells, specifically fibroblasts and immune cells, play a crucial role in nipple development, essential for successful lactation, despite no issues with mammary morphology or milk production.

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community Just found a little hard lump under my left nipple, it’s over

in Finasteride/Dutasteride 12 upvotes 2 years ago

A user experienced a hard lump under their nipple and increased hair loss after four months of finasteride. They are concerned about the lump and plan to stop the treatment.

community 13 Years on Fin, Losing Effectiveness, Started 0.5 Dut Once a Week, Getting Strange Nipple Sensitivity, Is This Something That Will Go Away? (Blood Test Results After 13 Years Included)

2 upvotes 1 year ago

After 13 years on finasteride, OP is experiencing reduced effectiveness and has started taking 0.5 mg of dutasteride weekly, noticing nipple sensitivity as a side effect. OP plans to increase the dutasteride dosage and retest hormone levels, while others suggest adjusting the dosage or trying different forms of dutasteride.

community Finasteride gyno experience and in dire need of advice

in Finasteride/Dutasteride 7 upvotes 6 years ago

A user experienced puffy nipples and lumps from finasteride, leading to a dilemma between continuing treatment with potential surgery or accepting hair loss. They restarted finasteride at a lower dose with supplements but still face side effects and are seeking advice on whether to persist or stop.

community Blood work results concerning ?? Finasteride

1 upvotes 1 year ago

A 23-year-old male experienced nipple sensitivity after taking 0.5 mg finasteride for 2.5 months, with blood tests showing increased testosterone and estrogen levels. He stopped finasteride temporarily and seeks advice to prevent gynecomastia.

community Finasteride users: have DIM supplements worked for you?

4 upvotes 1 week ago

A user started finasteride and is experiencing fatigue and nipple tenderness. They are considering DIM supplements to manage elevated estrogen levels, and another user suggests these side effects may resolve in a month.

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