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GlossaryMucin Deposition

accumulation of gel-like mucin within tissues

Mucin deposition refers to the accumulation of mucin, a gel-like substance produced by epithelial cells, within tissues. In the context of hair and skin, excessive mucin deposition can occur in conditions like alopecia mucinosa, where it disrupts normal hair follicle function and leads to hair loss. This process can be identified through histological examination, where mucin appears as a clear, amorphous material within the dermis.

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research Acneiform Follicular Mucinosis

19 citations, July 2004 in “Clinical and experimental dermatology”

Acneiform follicular mucinosis can be controlled with systemic corticosteroids.

research Clinical and Microscopic Features of Generalized Discoid Lupus Erythematosus in Dogs (10 Cases)

20 citations, October 2016 in “Veterinary dermatology”

Dogs with generalized discoid lupus erythematosus have similar symptoms to humans and need continuous treatment.

Clinical and Histological Characterization of Multifocal, Spontaneous, Noninfectious Alopecia in Norwegian Puffin Dogs (Lundehunds)

research Clinical and Histological Characterization of Multifocal, Spontaneous, Noninfectious Alopecia in Norwegian Puffin Dogs (Lundehunds)

3 citations, March 2014 in “Veterinary dermatology”

Norwegian puffin dogs have a unique type of hair loss that often doesn't get better on its own and responds well to ciclosporin treatment.

research Lipedematous Alopecia with Mucinosis: Report of the First Case in Taiwan

2 citations, March 2011 in “Dermatologica Sinica”

Taiwan reported its first case of a rare scalp condition with no clear cause or treatment.

Conventional Histopathology and New Technologies in Cutaneous Mucinoses: Old Diagnostic Criteria and New Therapeutic Perspectives

research Conventional Histopathology and New Technologies in Cutaneous Mucinoses: Old Diagnostic Criteria and New Therapeutic Perspectives

June 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

New technologies show potential for better understanding and treating skin conditions with abnormal mucin, but more research is needed for clinical use.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.