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Minimal Systemic Exposure of a New Topical Triazole Antifungal, Efinaconazole 10% Solution, in Patients with Severe Onychomycosis Following 28-Day Treatment

research Minimal systemic exposure of a new topical triazole antifungal, efinaconazole 10% solution, in patients with severe onychomycosis following 28-day treatment

February 2013 in “Journal of The American Academy of Dermatology”

Hair loss is a common but often unreported side effect of cancer treatments, especially for breast and prostate cancers.

Methotrexate Dose Has Minimal Effects on Methotrexate-Related Toxicity in Patients with Early Rheumatoid Arthritis Treated in Combination with Adalimumab – Results of Concerto Trial

research THU0239 Methotrexate Dose has Minimal Effects on Methotrexate-Related Toxicity in Patients with Early Rheumatoid Arthritis Treated in Combination with Adalimumab – Results of Concerto Trial

June 2013 in “Annals of the rheumatic diseases”

This study concluded that while methotrexate-related adverse events were infrequent in early rheumatoid arthritis patients taking adalimumab, some increased with higher methotrexate doses, suggesting use of the lowest effective dose.

research The Advantages of Topical a Cell Delivered Concert with Minimal Depth FUE Procedures: A Single Case Study

December 2019 in “International Journal of Cell Science & Molecular Biology”

Weekly Docetaxel in Minimally Pretreated Cancer Patients: A Dose-Escalation Study Focused on Feasibility and Cumulative Toxicity of Long-Term Administration

research Weekly docetaxel in minimally pretreated cancer patients: A dose-escalation study focused on feasibility and cumulative toxicity of long-term administration

50 citations , June 1999 in “Annals of Oncology”

This study found that long-term weekly administration of docetaxel is feasible at doses up to 45 mg/m² per week with acceptable toxicity, and suggests further evaluation with 40 mg/m² for phase II studies.

research Copper−Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

102 citations , October 2010 in “Molecular Pharmaceutics”

In this study, copper-doxorubicin liposomes with multidose therapy reduced systemic toxicity compared to ammonium sulfate-loaded doxorubicin liposomes, while combinatorial strategies further enhanced tumor regression and accumulation.

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community Minimal dose of topical minioxidil for microdosing finisteride 0.0025

in Research/Science 2 upvotes 2 years ago

Using a microdose of finasteride on the scalp with minoxidil as a carrier may have positive effects with minimal side effects. The user is also considering the effects of sulforaphane or broccoli sprouts on hair loss.

community Topical dutasteride significantly outperforms oral finasteride

in Research/Science 65 upvotes 11 months ago

Topical dutasteride 0.05% is reported to outperform oral finasteride with minimal side effects, but concerns about study bias exist due to company funding. Some users report mixed results with topical dutasteride, noting issues with skin penetration and systemic absorption.

community 4 months topical minoxidil + 2 months finasteride

in Minoxidil 132 upvotes 1 year ago

Topical minoxidil and oral finasteride are effectively promoting hair growth with minimal side effects, such as no impact on sex drive. Users report positive results and reduced hair shedding, with some using a combination of topical foam containing both minoxidil and finasteride.

community Topical melatonin shows some promise.

4 upvotes 10 years ago

Topical melatonin shows promise for increasing hair density with minimal side effects. The user is transitioning from oral finasteride to a compounded minoxidil and finasteride solution and considering melatonin and bimatoprost as additional treatments.

community Anyone with experience/knowledge on topical dutasteride?

in Finasteride/Dutasteride 5 upvotes 2 months ago

A dermatologist recommended 0.5% topical dutasteride for minimal hair loss, but users suggest starting with lower concentrations or using minoxidil and finasteride. Light microneedling before applying dutasteride and using a liposomal base for better absorption were also discussed.

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