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Did you mean Melanocortin 1 Receptor?

GlossaryMelanocortin 1 Receptor

regulates melanin production, affecting hair and skin color

The Melanocortin 1 Receptor (MC1R) is a protein found on the surface of melanocytes, the cells responsible for producing melanin, the pigment that gives skin, hair, and eyes their color. Variations in the MC1R gene can influence hair color, skin tone, and susceptibility to UV radiation, and are also associated with red hair and fair skin.

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research Down-Regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in Xenopus Melanophores

43 citations, May 1999 in “Journal of Biological Chemistry”

Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.

research Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss

9 citations, November 2012 in “Archives of Dermatological Research”

MC4R gene variants not linked to female hair loss.

research Receptors in Trichology: Hot Spots for Hair Regeneration

January 2013 in “International journal of trichology”

Vitamin D3 and its receptor are important for hair growth, and understanding receptors could help treat hair graying and skin cancer.

research Piecing Together the Pigment-Type Switching Puzzle

10 citations, November 2009 in “Pigment cell & melanoma research”

The document concludes that MGRN1 affects mouse fur color by interfering with a receptor's signaling, but its full role in the body is still unknown.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations, April 2016 in “Cell Reports”

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

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