18 citations
,
March 2023 in “Molecular Therapy — Nucleic Acids” In this study, adding CCL2 protein to organoid cultures helped adult skin cells regain the ability to self-organize and regenerate hair follicles, suggesting potential therapeutic applications.
2 citations
,
October 2023 in “Science advances” In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative review from the authors discusses mechanical scalp stimulation as a potential treatment for androgenetic alopecia, suggesting it has a biologically plausible mechanism but immature clinical evidence; marketing of these devices currently outpaces their supporting data, indicating a need for better-controlled trials.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This narrative review suggests that while mechanical scalp stimulation has a plausible mechanism for aiding androgenetic alopecia, its clinical evidence is insufficient, and the marketing of stimulation devices currently outpaces their efficacy data.
5 citations
,
August 2023 in “Skin Research and Technology” In this study, fMRI results suggested that mechanical stimulation evoked a stronger prickle sensation comprising both pain and itch on hairy skin compared to glabrous skin.