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research Endocannabinoids limit excessive mast cell maturation and activation in human skin

124 citations , January 2012 in “Journal of Allergy and Clinical Immunology”

This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.

research Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin

115 citations , November 2004 in “Brain Behavior and Immunity”

This study found that stress increases the number of peptidergic nerve fibers and mast cell activity in mouse skin, suggesting a significant neuro-immune interaction under stress.

research A simple immunofluorescence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle - dependent changes in mast cell - nerve fiber contacts in murine skin

109 citations , April 1997 in “Archives of Dermatological Research”

The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.

research Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition

76 citations , March 2005 in “Journal of Molecular Medicine”

This study found that premature hair loss due to stress does not occur in NK-1 receptor knockout or mast cell deficient mice, suggesting a key role for neurokinin substance P and mast cell interaction in stress-related hair follicle changes.

research Acne: a side‐effect of masculinizing hormonal therapy in transgender patients

57 citations , August 2018 in “British Journal of Dermatology”

This review discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and reports no new clinical results, emphasizing the need for tailored guidelines.

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Community Join

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community Massive shed on the section of my head where I didn't get a transplant.

5 upvotes 2 days ago

The user experienced significant hair shedding in areas not covered by a previous hair transplant, despite using finasteride and minoxidil for two years. They are advised to consult a dermatologist for professional guidance, as the shedding could be due to various reversible causes.

community Massive hairloss post dermaroller

in Microneedling 4 upvotes 2 weeks ago

The user experienced significant hair loss and thinning after using a dermaroller weekly, despite being on topical Minoxidil daily and oral Finasteride every other day. Microneedling can cause shedding, which may explain the hair loss.

community Massive shedding not stoping for more than 2 months

in Treatment 8 upvotes 1 month ago

A 21-year-old with AGA and seborrheic dermatitis experienced significant hair improvement using 1 mg finasteride and 2 mg oral minoxidil but began shedding heavily after a few months. Despite not missing any doses, the shedding persisted for over two months, causing concern about the effectiveness of the treatment.

community Massive Shed at 9/10 Months In

132 upvotes 4 months ago

The conversation discusses hair shedding experienced by users undergoing hair loss treatments, including finasteride, minoxidil, and microneedling. Many users report experiencing significant shedding around the 8-12 month mark, which is considered a normal part of the hair regrowth process, with expectations of stronger regrowth following the shedding phase.

community Massaging scalp, day 163, Update. NEED ADVICE!!

in Chat 4 upvotes 6 months ago

The conversation discusses hair loss treatments, including scalp massage, and the importance of blocking DHT for hair loss management. The user shares blood test results, which appear normal, and seeks advice on effective tests and treatments, expressing a preference for natural methods over medication.

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Learn

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learn Aloe vera

ried everything but your hair keeps falling? A DIY aloe hair mask might be what nature ordered. Aloe hair masks can help nourish hair but won't stop medical hair loss.

learn PP405

Can applying a mask with PP405 directly to thinning areas give your scalp the push it needs? No PP405 mask exists to test: PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, it is not an anti-DHT ingredient, and it is not on sale. Its registered Phase 2 trial (NCT06393452) measured safety, not regrowth, and a rinse-out mask is in any case the wrong format for reaching the follicle.

learn Vitamin B5

Can a vitamin B5-rich hair mask rescue your strands when no shampoo seems to work? A vitamin B5-rich hair mask can improve hair health but won't replace shampoo.

learn Centella

Could a flaxseed-based hair mask help fight off the DHT effect in your scalp? There is no verifiable evidence that flaxseed lowers DHT or that its lignans penetrate the scalp; a flaxseed gel mask is a cheap emollient that may soothe an irritated scalp, and it is not a treatment for androgenetic alopecia.
Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.