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research Significant Hair Regrowth With 5% Topical Minoxidil in a Child With Marie Unna Hereditary Hypotrichosis Caused by a Recurrent HRURF Variant

August 2025 in “Journal of Cosmetic Dermatology”

This study reported significant short-term scalp hair regrowth and increased density in a 4-year-old with Marie Unna hereditary hypotrichosis following topical 5% minoxidil treatment, suggesting its potential benefit in this condition.

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

In this study, researchers linked defects in U2HR, an inhibitory region in the HR gene, to Marie Unna hereditary hypotrichosis, suggesting a mechanism for controlling hair growth and addressing hair loss.

research Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a U2HR mutation

11 citations , September 2010 in “American Journal of Medical Genetics - Part A”

This study reports a mutation in the U2HR gene causing Marie Unna hereditary hypotrichosis in a Turkish family and notes eyebrow loss as a diagnostic clue.

research Differential diagnosis of hair loss in children. Differentialdiagnose des Haarausfalls bei Kindern

30 citations , May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft”

This review proposes a classification system for childhood hair loss based on clinical appearance, age of onset, and associated symptoms, but reports no new clinical results.

research Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity

January 2025 in “Clinical Cosmetic and Investigational Dermatology”

This article reports the first documented cases of Marie-Unna hereditary hypotrichosis in Egypt, highlighting the variability of genetic mutations in this rare form of congenital hair loss.

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Clinics

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Community Join

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community My hair journey as a 20+ year old with genetic hair loss and thoughts of pregnancy soon

in Female 1 upvotes 1 year ago

A 28-year-old woman with genetic hair loss has tried various treatments, including oral minoxidil, finasteride, dutasteride, vitamins, ketoconazole shampoo, exosome needling, and hair extensions. She plans to pause treatments for pregnancy and is concerned about potential hair loss during that time.

community Woman with hairloss, want to hear from other women with same problem

4 upvotes 9 years ago

A woman experiencing hair loss is trying iron, biotin, and B12 supplements, increasing meat intake, and improving hydration to address her condition. Another person suggests checking vitamin D levels, stress, thyroid, and hormones, and recommends seeing a dermatologist for a proper diagnosis.

community Hair Loss Journey so far and where to now (22yo)

in Is this regrowth? 2 upvotes 1 year ago

The user is experiencing hair loss and is using topical finasteride, rosemary oil, caffeine, microneedling, low-level laser therapy, scalp massages, ketoconazole shampoo, and various vitamins and supplements. They are concerned about potential gynecomastia and are considering using minoxidil if current treatments do not stop hair loss or promote regrowth.

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Learn

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learn Rosemary

Can rosemary prevent hair loss before it starts? No study has tested whether rosemary prevents hair loss; the one small human trial treated people who already had pattern hair loss. Early thinning is a reason to see a doctor about treatments with stronger evidence.

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas