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This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.

In this study involving male mice, Mangkokan leaf extract (Polyscias scutellaria) at a 7% concentration was found to heal incision wounds faster compared to 3% and 5% concentrations.

This study found that a phytosome lotion made from Mangkokan leaf extract, using a green solvent and microwave-assisted extraction, demonstrated greater hair growth activity than 2% minoxidil, with the 30% phytosome lotion showing the highest efficacy in increasing hair length, weight, and diameter.

This study formulated two herbal shampoos using natural extracts and reported that their physicochemical properties were comparable to commercial shampoos.

This study found that the ethanol extract of mangkokan leaf (Polyscias scutellarium) demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, with higher concentrations showing greater inhibition zones, particularly against Staphylococcus aureus.