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Glossary Liquid Chromatography-Tandem Mass Spectrometry

combines separation and identification of compounds in samples

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an advanced analytical technique used to identify and quantify compounds in a sample. It combines liquid chromatography, which separates the mixture into its individual components, with tandem mass spectrometry, which provides detailed information about the molecular structure and quantity of each component. This method is highly sensitive and precise, making it valuable in fields like pharmacology, biochemistry, and environmental science.

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Determination of Finasteride in Human Plasma by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry with Flow Rate Gradient

research Determination of finasteride in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry with flow rate gradient

2 citations , October 2010 in “European Journal of Drug Metabolism and Pharmacokinetics”

Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.

Highly Sensitive Simultaneous Measurement of Steroid Hormone in Human Serum by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry

research Highly Sensitive Simultaneous Measurement of Steroid Hormone in Human Serum by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry

March 2022 in “VNU Journal of Science Medical and Pharmaceutical Sciences”

This study developed a sensitive method using LC-ESI-MS/MS for accurate and reliable measurement of nine steroid hormones in children's serum.

Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry: Application to a Comparative Pharmacokinetics Study

research Finasteride Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry. Application to a Comparative Pharmacokinetics Study

1 citations , April 2015 in “Drug research”

This study concluded that two different pharmaceutical formulations of finasteride were bioequivalent in terms of rate and extent of absorption based on pharmacokinetic evaluations in a randomized crossover study with 38 volunteers.

Ultra-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry for the Determination of Ketoconazole in Anti-Dandruff Shampoo

research Ultra-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry for the Determination of Ketoconazole in Anti-Dandruff Shampoo

1 citations , February 2014 in “Analytical Letters”

This study developed a fast and sensitive ultra-high performance liquid chromatography method to quantify ketoconazole in antidandruff emulsions, showing comparable results to labeled concentrations.

research Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

22 citations , January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study developed and validated a mass spectrometric method to measure hydroxy-androgens in serum, which aids in understanding androgen synthesis in castration resistant prostate cancer.

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community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

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