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Did you mean Lipocalin-type Prostaglandin D Synthase?

GlossaryLipocalin-type Prostaglandin D Synthase

enzyme involved in producing prostaglandin D2, affecting sleep and hair growth

Lipocalin-type Prostaglandin D Synthase (L-PGDS) is an enzyme that plays a crucial role in the production of prostaglandin D2, a compound involved in various physiological processes such as sleep regulation, inflammation, and hair growth. Also known as Beta-trace protein, L-PGDS is found in the brain and cerebrospinal fluid, and its levels can be used as a biomarker for certain neurological conditions.

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research Structural and Dynamic Insights into Substrate Binding and Catalysis of Human Lipocalin Prostaglandin D Synthase

20 citations, March 2013 in “Journal of Lipid Research”

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

research Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

18 citations, October 2021 in “Frontiers in Physiology”

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

research High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

5 citations, July 2014 in “Acta Crystallographica Section D-biological Crystallography”

Mutations in the enzyme don't significantly change how it binds to its specific substances.

research A Prostaglandin D-Synthase-Positive Mast Cell Gradient Characterizes Scalp Patterning

6 citations, December 2013 in “Journal of Cutaneous Pathology”

Certain immune cells are more common on the top of the head and might help predict or treat common hair loss.

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community Painkillers May Block Minoxidil

in Research/Science 15 upvotes 2 weeks ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community Please listen. If you want to save your hair.

in Progress Pictures 126 upvotes 2 years ago

User discusses two medications for stopping hair loss: Fin (finasteride) and Dut (dutasteride). Mixed experiences and side effects are shared, with some users seeing positive results.

community Topical Dutasteride is Here.

in Finasteride/Dutasteride 153 upvotes 4 years ago

The availability of Topical Dutasteride, a potential treatment for hair loss, which can be purchased without prescription from MinoxidilMax. Other treatments discussed include Topical Finasteride and PRP injections, with discussion around dosage, efficacy, side-effects and safety.