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    GlossaryEnhancer of Zeste Homolog 2

    gene encoding an enzyme that represses gene expression via methylation

    Enhancer of Zeste Homolog 2 (EZH2) is a gene that encodes an enzyme involved in modifying chromatin, which is the complex of DNA and proteins in the cell nucleus. This enzyme adds methyl groups to histone proteins, leading to the repression of gene expression. EZH2 is important in regulating cell division and differentiation, and its dysregulation is often associated with various cancers.

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