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    GlossaryNon-Classical Adrenal Hyperplasia (Late-onset Congenital Adrenal Hyperplasia)

    partial enzyme deficiency causing excess androgen production

    Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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      An essential vasodilator with some anti-androgenic effects, has excellent safety record

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      An Update on Congenital Adrenal Hyperplasia

      research An Update on Congenital Adrenal Hyperplasia

      151 citations, December 2004 in “Annals of the New York Academy of Sciences”
      Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.
      Hirsutism in Young Girls: Beyond PCOS

      research Hirsutism in Young Girls: Beyond PCOS

      October 2024 in “Journal of the Endocrine Society”
      Hirsutism in young girls can have causes other than PCOS, so diagnoses should be reassessed if treatments don't work.
      Menstrual Irregularity in Hirsute Women

      research Menstrual Irregularity in Hirsute Women

      September 1997 in “Journal of the European Academy of Dermatology and Venereology”
      Hirsute women with ovarian-sourced hirsutism are more likely to have irregular periods, with higher BMI and altered hormone ratios.

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