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research Lack of Collagen VI Promotes Wound-Induced Hair Growth

32 citations , May 2015 in “Journal of Investigative Dermatology”

This study found that collagen VI influences hair follicle growth and wound-induced regrowth by activating the Wnt/β-catenin signaling pathway in mice, suggesting potential therapeutic targets for hair loss.

research LACK OF EFFECT OF OESTROGENS ON ADRENAL ANDROGEN SECRETION IN CHILDREN AND ADOLESCENTS WITH A COMMENT ON OESTROGENS AND PUBIC HAIR GROWTH

26 citations , March 1981 in “Clinical Endocrinology”

In this study, researchers found that oestrogen did not increase adrenal androgen secretion in children with premature adrenarche or in adolescents with gonadal dysgenesis undergoing oestrogen replacement therapy.

research Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.

research Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women

16 citations , October 2009 in “Dermatology”

This study found that a cream containing spironolactone did not affect hair growth in hirsute women.

research Biotin and Acetazolamide for Treatment of an Unusual Child With Autism Plus Lack of Nail and Hair Growth

10 citations , October 2017 in “Pediatric neurology”

This case report suggests that poor hair and nail growth in children with autism spectrum disorder and developmental delay may indicate a biotin-responsive condition, as biotin and acetazolamide therapy improved symptoms and school performance in the reported patient.

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community Hypoxia (lack of oxygen) enhances hair growth via stem cells

49 upvotes 1 year ago

Hypoxia may enhance hair growth by stimulating stem cells, but it could also risk fibrosis. Some users humorously discuss extreme methods like choking while using minoxidil, highlighting the need for new treatments.

community 3 months in on my hair-growth regime and Im losing hope...

4 upvotes 6 years ago

The user is frustrated with their lack of hair growth after 3.5 months of using minoxidil, dermarolling, Propidren (Saw Palmetto), and essential oil massages. They are hesitant to use finasteride due to potential side effects, despite suggestions that it might be more effective.

community 2-deoxy-D-ribose (2dDR), a sugar molecule, was found to be 80%-90% as effective as minoxidil in promoting hair growth and neovascularization in androgenic alopecia models, showing promise for alopecia treatment.

in Research/Science 18 upvotes 2 years ago

2-deoxy-D-ribose, a sugar molecule, is found to be 80%-90% as effective as Minoxidil in promoting hair growth, showing potential for alopecia treatment. Concerns include high cost, lack of human studies, and possible side effects like diarrhea and nausea.

community Jeff Vincent and his stealth drug growth stimulant is on track for Q1 2027

89 upvotes 1 month ago

A new hair growth drug claims to reverse severe hair loss without using minoxidil, finasteride, or hormone-altering drugs, but many are skeptical due to lack of evidence and concerns about misleading claims. The drug is expected to be released in early 2027, but its legitimacy is questioned.

community 4.5 months on minox and seeing basically 0 growth, GOING BALLS DEEP

4 upvotes 3 years ago

The user is frustrated with the lack of hair growth after using minoxidil for nearly 5 months and plans to intensify their treatment with additional products like tretinoin cream, stemoxydine, and microneedling, while continuing finasteride. They are considering a hair transplant in the future and are cautious about starting oral minoxidil due to past heart issues.

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Learn

10 / 13 results

learn Procyanidin

Are Procyanidin based hair tonics or shampoos effective against androgenic alopecia? Procyanidin-based hair tonics may promote hair growth but lack definitive evidence for AGA.

learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

learn Epidermal Growth Factor

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn Caffeine

Does caffeine stimulate hair growth or only slow hair loss? Caffeine stimulates hair follicles in laboratory cultures, and one open-label trial in 210 men found a 0.2% caffeine topical non-inferior to minoxidil 5% on an anagen-ratio endpoint; there is no placebo-controlled evidence that it regrows hair, and none at all in alopecia areata or telogen effluvium.

learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

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