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GlossaryKeratin 6 (KRT6)

protein in skin, hair, and nails providing structural support

Keratin 6 (K6) is a type of protein found in the epithelial cells of the skin, hair, and nails. It plays a crucial role in the structural integrity and resilience of these tissues. Mutations in the KRT6 gene, which encodes Keratin 6, can lead to disorders such as pachyonychia congenita, characterized by thickened nails and other skin abnormalities.

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Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

research Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in certain mice is linked to changes in keratin-related genes.

research Differential Expression of Keratin and Keratin Associated Proteins Are Linked with Hair Loss Condition in Spontaneously Mutated Inbred Mice

November 2024 in “Biochemical and Biophysical Research Communications”

Abnormal gene expression related to keratin causes hair loss in certain mice.

research Significance of Stress Keratin Expression in Normal and Diseased Epithelia

47 citations , January 2024 in “iScience”

Stress keratins are expressed less in diseased skin and are linked to differentiation, inflammation, and immunity.

Genetic Variants in Pachyonychia Congenita-Associated Keratins Increase Susceptibility to Tooth Decay

research Genetic Variants in Pachyonychia Congenita-Associated Keratins Increase Susceptibility to Tooth Decay

21 citations , January 2018 in “PLoS Genetics”

Certain genetic variants in keratins increase the risk of tooth decay.

Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

17 citations , February 2015 in “Cell Death and Disease”

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

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